Seroatlas · Human Serome Atlas

NBR1

Next to BRCA1 gene 1 protein

Also known as: 1A1-3B, CA125, KIAA0049, M17S2, NBR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q14596
Gene: NBR1
Ensembl: ENSG00000188554
Chromosome: 17
Canonical length: 966 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear bodies,Vesicles
Quaternary structure: Homooligomer

OverviewNCBI Gene

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

966 residues, UniProt reviewed canonical sequence.

>Q14596|NBR1
     1  MEPQVTLNVT FKNEIQSFLV SDPENTTWAD IEAMVKVSFD LNTIQIKYLD EENEEVSINS
    61  QGEYEEALKM AVKQGNQLQM QVHEGHHVVD EAPPPVVGAK RLAARAGKKP LAHYSSLVRV
   121  LGSDMKTPED PAVQSFPLVP CDTDQPQDKP PDWFTSYLET FREQVVNETV EKLEQKLHEK
   181  LVLQNPSLGS CPSEVSMPTS EETLFLPENQ FSWHIACNNC QRRIVGVRYQ CSLCPSYNIC
   241  EDCEAGPYGH DTNHVLLKLR RPVVGSSEPF CHSKYSTPRL PAALEQVRLQ KQVDKNFLKA
   301  EKQRLRAEKK QRKAEVKELK KQLKLHRKIH LWNSIHGLQS PKSPLGRPES LLQSNTLMLP
   361  LQPCTSVMPM LSAAFVDENL PDGTHLQPGT KFIKHWRMKN TGNVKWSADT KLKFMWGNLT
   421  LASTEKKDVL VPCLKAGHVG VVSVEFIAPA LEGTYTSHWR LSHKGQQFGP RVWCSIIVDP
   481  FPSEESPDNI EKGMISSSKT DDLTCQQEET FLLAKEERQL GEVTEQTEGT AACIPQKAKN
   541  VASERELYIP SVDLLTAQDL LSFELLDINI VQELERVPHN TPVDVTPCMS PLPHDSPLIE
   601  KPGLGQIEEE NEGAGFKALP DSMVSVKRKA ENIASVEEAE EDLSGTQFVC ETVIRSLTLD
   661  AAPDHNPPCR QKSLQMTFAL PEGPLGNEKE EIIHIAEEEA VMEEEEDEED EEEEDELKDE
   721  VQSQSSASSE DYIIILPECF DTSRPLGDSM YSSALSQPGL ERGAEGKPGV EAGQEPAEAG
   781  ERLPGGENQP QEHSISDILT TSQTLETVPL IPEVVELPPS LPRSSPCVHH HGSPGVDLPV
   841  TIPEVSSVPD QIRGEPRGSS GLVNSRQKSY DHSRHHHGSS IAGGLVKGAL SVAASAYKAL
   901  FAGPPVTAQP IISEDQTAAL MAHLFEMGFC DRQLNLRLLK KHNYNILQVV TELLQLNNND
   961  WYSQRY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NBR1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 132 nTPM

Expression across tissuesHPA

Tissue

testis: 132 nTPM
tongue: 108 nTPM
skeletal muscle: 104 nTPM
parathyroid gland: 91 nTPM
liver: 85 nTPM
kidney: 79 nTPM

Single-cell type

late spermatids: 1,687 nCPM
early spermatids: 346 nCPM
neutrophils: 208 nCPM
prostatic club cells: 139 nCPM
prostatic glandular cells: 139 nCPM
enterocytes: 130 nCPM

Immune cell

basophil: 42 nTPM
eosinophil: 40 nTPM
non-classical monocyte: 37 nTPM
neutrophil: 35 nTPM
T-reg: 27 nTPM
classical monocyte: 26 nTPM

Brain region

white matter: 109 nTPM
basal ganglia: 89 nTPM
medulla oblongata: 89 nTPM
cerebellum: 87 nTPM
spinal cord: 87 nTPM
choroid plexus: 85 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 1.36
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

PB1 domain
Zinc finger, ZZ-type
UBA-like superfamily
Immunoglobulin-like fold
Ubiquitin-associated domain
Nbr1, FW domain
Zinc finger, ZZ-type superfamily
PB1-like domain
PB1 domain
Zinc finger, ZZ type
Ig-like domain from next to BRCA1 gene
Nbr1, PB1 domain
Nbr1-like, C-terminal UBA domain
Next to BRCA1 gene 1 protein-like, C-terminal UBA domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NBR1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NBR1 as an antibody target. Whether an autoantibody or antibody against NBR1 could matter depends on whether native NBR1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NBR1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NBR1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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