Seroatlas · Human Serome Atlas

TBC1D25

TBC1 domain family member 25

Also known as: OATL1, TBC25_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3MII6
Gene: TBC1D25
Ensembl: ENSG00000068354
Chromosome: X
Canonical length: 688 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a protein with a TBC domain and functions as a Rab GTPase activating protein. The encoded protein is involved in the fusion of autophagosomes with endosomes and lysosomes. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

688 residues, UniProt reviewed canonical sequence.

>Q3MII6|TBC1D25
     1  MATASGASDL SGSGAPPPGV GAQAAAAAEE EEREVVRVRV KKCESFLPPE FRSFAVDPQI
    61  TSLDVLQHIL IRAFDLSGKK NFGISYLGRD RLGQEVYLSL LSDWDLSTAF ATASKPYLQL
   121  RVDIRPSEDS PLLEDWDIIS PKDVIGSDVL LAEKRSSLTT AALPFTQSIL TQVGRTLSKV
   181  QQVLSWSYGE DVKPFKPPLS DAEFHTYLNH EGQLSRPEEL RLRIYHGGVE PSLRKVVWRY
   241  LLNVYPDGLT GRERMDYMKR KSREYEQLKS EWAQRANPED LEFIRSTVLK DVLRTDRAHP
   301  YYAGPEDGPH LRALHDLLTT YAVTHPQVSY CQGMSDLASP ILAVMDHEGH AFVCFCGIMK
   361  RLAANFHPDG RAMATKFAHL KLLLRHADPD FYQYLQEAGA DDLFFCYRWL LLELKREFAF
   421  DDALRMLEVT WSSLPPDPPE HEVELVGPPS QVADAGFGGH RGWPVRQRHM LRPAGGGGST
   481  FEDAVDHLAT ASQGPGGGGR LLRQASLDGL QQLRDNMGSR RDPLVQLPHP AALISSKSLS
   541  EPLLNSPDPL LSSFSHPDSP SSSSPPSTQE ASPTGDMAVG SPLMQEVGSP KDPGKSLPPV
   601  PPMGLPPPQE FGRGNPFMLF LCLAILLEHR DHIMRNGLDY NELAMHFDRL VRKHHLGRVL
   661  RRARALFADY LQSEVWDSEE GAEATAAS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TBC1D25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.42
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 14 nTPM
heart muscle: 11 nTPM
skin: 10 nTPM
cerebral cortex: 9.9 nTPM
skeletal muscle: 9.4 nTPM
spleen: 9.4 nTPM

Single-cell type

late spermatids: 62 nCPM
neutrophils: 29 nCPM
rod photoreceptor cells: 29 nCPM
platelets: 27 nCPM
erythrocyte progenitors: 25 nCPM
basal keratinocytes: 24 nCPM

Immune cell

gdT-cell: 6.6 nTPM
memory CD8 T-cell: 5.6 nTPM
eosinophil: 5.4 nTPM
MAIT T-cell: 5.1 nTPM
naive CD8 T-cell: 4.9 nTPM
naive B-cell: 4.8 nTPM

Brain region

cerebellum: 20 nTPM
cerebral cortex: 19 nTPM
basal ganglia: 17 nTPM
pons: 17 nTPM
hypothalamus: 17 nTPM
hippocampal formation: 17 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TBC1D25.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 95 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Oligospermia

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.47
gnomAD pLI: 0.52
gnomAD missense Z: 3.1
DepMap mean gene effect: -0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

GTPase activator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TBC1D25 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TBC1D25 as an antibody target. Whether an autoantibody or antibody against TBC1D25 could matter depends on whether native TBC1D25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TBC1D25 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TBC1D25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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