Seroatlas · Human Serome Atlas

RETREG2

Reticulophagy regulator 2

Also known as: C2orf17, FAM134A, MAG-2, MGC3035, RETR2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8NC44
Gene
RETREG2
Ensembl
ENSG00000144567
Chromosome
2
Canonical length
543 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable endoplasmic reticulum-autophagosome adaptor activity. Predicted to be involved in autophagy. Predicted to act upstream of or within collagen catabolic process; endoplasmic reticulum organization; and reticulophagy. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>Q8NC44|RETREG2
     1  MASGGGGGNT GAGGGPGMGL SLGLGLGLSL GMSEATSEAE EEAATAEAVG RLATTLWLRL
    61  RGWEAVLAAA QRLLVWEKPL HSLVTAAALN GLFWLLSSSS LRPFFLLSVS LLAYFLLDLW
   121  QPRFLPDVSA SSPEEPHSDS EGAGSGARPH LLSVPELCRY LAESWLTFQI HLQELLQYKR
   181  QNPAQFCVRV CSGCAVLAVL GHYVPGIMIS YIVLLSILLW PLVVYHELIQ RMYTRLEPLL
   241  MQLDYSMKAE ANALHHKHDK RKRQGKNAPP GGDEPLAETE SESEAELAGF SPVVDVKKTA
   301  LALAITDSEL SDEEASILES GGFSVSRATT PQLTDVSEDL DQQSLPSEPE ETLSRDLGEG
   361  EEGELAPPED LLGRPQALSR QALDSEEEEE DVAAKETLLR LSSPLHFVNT HFNGAGSPPD
   421  GVKCSPGGPV ETLSPETVSG GLTALPGTLS PPLCLVGSDP APSPSILPPV PQDSPQPLPA
   481  PEEEEALTTE DFELLDQGEL EQLNAELGLE PETPPKPPDA PPLGPDIHSL VQSDQEAQAV
   541  AEP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RETREG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
3
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
102 nTPM

Expression across tissuesHPA

Tissue

  • testis: 102 nTPM
  • cerebral cortex: 79 nTPM
  • cerebellum: 76 nTPM
  • parathyroid gland: 72 nTPM
  • basal ganglia: 68 nTPM
  • hippocampal formation: 58 nTPM

Single-cell type

  • late spermatids: 306 nCPM
  • late primary spermatocytes: 236 nCPM
  • cardiomyocytes: 98 nCPM
  • kupffer cells: 91 nCPM
  • epididymal clear cells: 90 nCPM
  • early spermatids: 82 nCPM

Immune cell

  • neutrophil: 24 nTPM
  • basophil: 13 nTPM
  • T-reg: 9.6 nTPM
  • memory CD8 T-cell: 9.5 nTPM
  • gdT-cell: 9.3 nTPM
  • naive CD8 T-cell: 8.8 nTPM

Brain region

  • thalamus: 66 nTPM
  • midbrain: 64 nTPM
  • medulla oblongata: 64 nTPM
  • spinal cord: 63 nTPM
  • pons: 63 nTPM
  • hypothalamus: 62 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.51
gnomAD pLI
0.25
DepMap mean gene effect
0.16
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RETREG2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RETREG2 as an antibody target. Whether an autoantibody or antibody against RETREG2 could matter depends on whether native RETREG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RETREG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RETREG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RETREG2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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