Seroatlas · Human Serome Atlas

ATG7

Ubiquitin-like modifier-activating enzyme ATG7

Also known as: APG7L, ATG7_HUMAN, DKFZp434N0735, GSA7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95352
Gene: ATG7
Ensembl: ENSG00000197548
Chromosome: 3
Canonical length: 703 aa
Protein class: Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Plasma membrane,Cytosol,Connecting piece,Flagellar centriole,Mid piece
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

703 residues, UniProt reviewed canonical sequence.

>O95352|ATG7
     1  MAAATGDPGL SKLQFAPFSS ALDVGFWHEL TQKKLNEYRL DEAPKDIKGY YYNGDSAGLP
    61  ARLTLEFSAF DMSAPTPARC CPAIGTLYNT NTLESFKTAD KKLLLEQAAN EIWESIKSGT
   121  ALENPVLLNK FLLLTFADLK KYHFYYWFCY PALCLPESLP LIQGPVGLDQ RFSLKQIEAL
   181  ECAYDNLCQT EGVTALPYFL IKYDENMVLV SLLKHYSDFF QGQRTKITIG VYDPCNLAQY
   241  PGWPLRNFLV LAAHRWSSSF QSVEVVCFRD RTMQGARDVA HSIIFEVKLP EMAFSPDCPK
   301  AVGWEKNQKG GMGPRMVNLS ECMDPKRLAE SSVDLNLKLM CWRLVPTLDL DKVVSVKCLL
   361  LGAGTLGCNV ARTLMGWGVR HITFVDNAKI SYSNPVRQPL YEFEDCLGGG KPKALAAADR
   421  LQKIFPGVNA RGFNMSIPMP GHPVNFSSVT LEQARRDVEQ LEQLIESHDV VFLLMDTRES
   481  RWLPAVIAAS KRKLVINAAL GFDTFVVMRH GLKKPKQQGA GDLCPNHPVA SADLLGSSLF
   541  ANIPGYKLGC YFCNDVVAPG DSTRDRTLDQ QCTVSRPGLA VIAGALAVEL MVSVLQHPEG
   601  GYAIASSSDD RMNEPPTSLG LVPHQIRGFL SRFDNVLPVS LAFDKCTACS SKVLDQYERE
   661  GFNFLAKVFN SSHSFLEDLT GLTLLHQETQ AAEIWDMSDD ETI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATG7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 31 nTPM
tonsil: 23 nTPM
lymph node: 21 nTPM
parathyroid gland: 20 nTPM
appendix: 19 nTPM
placenta: 19 nTPM

Single-cell type

neutrophils: 1,939 nCPM
oocytes: 1,418 nCPM
neutrophil progenitors: 1,324 nCPM
hofbauer cells: 658 nCPM
macrophages: 566 nCPM
monocytes: 559 nCPM

Immune cell

classical monocyte: 101 nTPM
neutrophil: 71 nTPM
eosinophil: 69 nTPM
myeloid DC: 66 nTPM
intermediate monocyte: 61 nTPM
basophil: 45 nTPM

Brain region

cerebral cortex: 66 nTPM
white matter: 65 nTPM
choroid plexus: 56 nTPM
thalamus: 54 nTPM
midbrain: 53 nTPM
medulla oblongata: 52 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ATG7.

Disease | AllUniProt

Conditions ATG7 is implicated in, by any mechanism.

Spinocerebellar ataxia, autosomal recessive, 31 (SCAR31) MIM:619422

Disease | GeneticClinVar

9 pathogenic / likely-pathogenic of 148 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Spinocerebellar ataxia, autosomal recessive 31
Nonpapillary renal cell carcinoma

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: 1.37
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein homodimerization activity
Atg12 activating enzyme activity
Atg8 activating enzyme activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

THIF-type NAD/FAD binding fold
Ubiquitin-activating enzyme-like
ThiF/MoeB/HesA family
ThiF family
Ubiquitin-like modifier-activating enzyme Atg7
Ubiquitin-like modifier-activating enzyme Atg7, N-terminal
Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 1
Ubiquitin-like modifier-activating enzyme Atg7, N-terminal, subdomain 2
Ubiquitin-like modifier-activating enzyme ATG7 N-terminus

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATG7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATG7 as an antibody target. Whether an autoantibody or antibody against ATG7 could matter depends on whether native ATG7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATG7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATG7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...