Seroatlas · Human Serome Atlas

CALCOCO2

Calcium-binding and coiled-coil domain-containing protein 2

Also known as: CACO2_HUMAN, MGC17318, NDP52

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13137
Gene
CALCOCO2
Ensembl
ENSG00000136436
Chromosome
17
Canonical length
446 aa
Protein class
Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene encodes a coiled-coil domain-containing protein. The encoded protein functions as a receptor for ubiquitin-coated bacteria and plays an important role in innate immunity by mediating macroautophagy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]

Canonical amino-acid sequenceUniProt

446 residues, UniProt reviewed canonical sequence.

>Q13137|CALCOCO2
     1  MEETIKDPPT SAVLLDHCHF SQVIFNSVEK FYIPGGDVTC HYTFTQHFIP RRKDWIGIFR
    61  VGWKTTREYY TFMWVTLPID LNNKSAKQQE VQFKAYYLPK DDEYYQFCYV DEDGVVRGAS
   121  IPFQFRPENE EDILVVTTQG EVEEIEQHNK ELCKENQELK DSCISLQKQN SDMQAELQKK
   181  QEELETLQSI NKKLELKVKE QKDYWETELL QLKEQNQKMS SENEKMGIRV DQLQAQLSTQ
   241  EKEMEKLVQG DQDKTEQLEQ LKKENDHLFL SLTEQRKDQK KLEQTVEQMK QNETTAMKKQ
   301  QELMDENFDL SKRLSENEII CNALQRQKER LEGENDLLKR ENSRLLSYMG LDFNSLPYQV
   361  PTSDEGGARQ NPGLAYGNPY SGIQESSSPS PLSIKKCPIC KADDICDHTL EQQQMQPLCF
   421  NCPICDKIFP ATEKQIFEDH VFCHSL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CALCOCO2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
159 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 159 nTPM
  • choroid plexus: 143 nTPM
  • skeletal muscle: 142 nTPM
  • testis: 127 nTPM
  • heart muscle: 127 nTPM
  • blood vessel: 123 nTPM

Single-cell type

  • early spermatids: 1,461 nCPM
  • late primary spermatocytes: 546 nCPM
  • retinal pigment epithelial cells: 414 nCPM
  • late spermatids: 410 nCPM
  • esophageal apical cells: 284 nCPM
  • kupffer cells: 255 nCPM

Immune cell

  • neutrophil: 134 nTPM
  • non-classical monocyte: 133 nTPM
  • intermediate monocyte: 122 nTPM
  • eosinophil: 116 nTPM
  • classical monocyte: 116 nTPM
  • basophil: 110 nTPM

Brain region

  • choroid plexus: 131 nTPM
  • white matter: 84 nTPM
  • medulla oblongata: 83 nTPM
  • hypothalamus: 74 nTPM
  • pons: 73 nTPM
  • basal ganglia: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.65
gnomAD pLI
0
gnomAD missense Z
0.91
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CALCOCO2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CALCOCO2 as an antibody target. Whether an autoantibody or antibody against CALCOCO2 could matter depends on whether native CALCOCO2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CALCOCO2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CALCOCO2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CALCOCO2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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