CDK5RAP3
CDK5 regulatory subunit-associated protein 3
Also known as: C53, CK5P3_HUMAN, FLJ13660, HSF-27, IC53, LZAP, MST016, OK/SW-cl.114
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96JB5
- Gene
- CDK5RAP3
- Ensembl
- ENSG00000108465
- Chromosome
- 17
- Canonical length
- 506 aa
- Protein class
- Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Nucleoli,Vesicles,Cytosol
OverviewNCBI Gene
This gene encodes a protein that has been reported to function in signaling pathways governing transcriptional regulation and cell cycle progression. It may play a role in tumorigenesis and metastasis. A pseudogene of this gene is located on the long arm of chromosome 20. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, May 2013]
Canonical amino-acid sequenceUniProt
506 residues, UniProt reviewed canonical sequence.
>Q96JB5|CDK5RAP3
1 MEDHQHVPID IQTSKLLDWL VDRRHCSLKW QSLVLTIREK INAAIQDMPE SEEIAQLLSG
61 SYIHYFHCLR ILDLLKGTEA STKNIFGRYS SQRMKDWQEI IALYEKDNTY LVELSSLLVR
121 NVNYEIPSLK KQIAKCQQLQ QEYSRKEEEC QAGAAEMREQ FYHSCKQYGI TGENVRGELL
181 ALVKDLPSQL AEIGAAAQQS LGEAIDVYQA SVGFVCESPT EQVLPMLRFV QKRGNSTVYE
241 WRTGTEPSVV ERPHLEELPE QVAEDAIDWG DFGVEAVSEG TDSGISAEAA GIDWGIFPES
301 DSKDPGGDGI DWGDDAVALQ ITVLEAGTQA PEGVARGPDA LTLLEYTETR NQFLDELMEL
361 EIFLAQRAVE LSEEADVLSV SQFQLAPAIL QGQTKEKMVT MVSVLEDLIG KLTSLQLQHL
421 FMILASPRYV DRVTEFLQQK LKQSQLLALK KELMVQKQQE ALEEQAALEP KLDLLLEKTK
481 ELQKLIEADI SKRYSGRPVN LMGTSLLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CDK5RAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Other membrane
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 146 nTPM
Expression across tissuesHPA
Tissue
- pancreas: 146 nTPM
- pituitary gland: 104 nTPM
- choroid plexus: 103 nTPM
- liver: 88 nTPM
- epididymis: 87 nTPM
- spleen: 86 nTPM
Single-cell type
- foveolar cells: 75 nCPM
- astrocytes: 70 nCPM
- bergmann glia: 65 nCPM
- oligodendrocytes: 48 nCPM
- gastric chief cells: 47 nCPM
- goblet cells: 46 nCPM
Immune cell
- non-classical monocyte: 68 nTPM
- intermediate monocyte: 64 nTPM
- classical monocyte: 63 nTPM
- eosinophil: 55 nTPM
- myeloid DC: 50 nTPM
- plasmacytoid DC: 46 nTPM
Brain region
- choroid plexus: 61 nTPM
- thalamus: 33 nTPM
- medulla oblongata: 31 nTPM
- white matter: 30 nTPM
- pons: 29 nTPM
- basal ganglia: 29 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.08
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.48
- DepMap mean gene effect
- -0.35
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- apoptotic nuclear changes
- brain development
- cell population proliferation
- definitive erythrocyte differentiation
- endoplasmic reticulum unfolded protein response
- liver development
- mitotic G2 DNA damage checkpoint signaling
- mitotic G2/M transition checkpoint
- negative regulation of MAP kinase activity
- negative regulation of NF-kappaB transcription factor activity
- negative regulation of protein catabolic process
- negative regulation of protein kinase activity by regulation of protein phosphorylation
- negative regulation of protein phosphorylation
- negative regulation of protein serine/threonine kinase activity
- positive regulation of protein localization to nucleus
- positive regulation of protein ubiquitination
- positive regulation of reticulophagy
- positive regulation of signal transduction by p53 class mediator
- positive regulation of transcription by RNA polymerase II
- protein ufmylation
- regulation of cyclin-dependent protein serine/threonine kinase activity
- regulation of mitotic cell cycle
- regulation of neuron differentiation
- regulation of phosphatase activity
- rescue of stalled ribosome
- response to endoplasmic reticulum stress
- ribosome disassembly
Molecular functions
- cyclin binding
- MDM2/MDM4 family protein binding
- mitogen-activated protein kinase binding
- NF-kappaB binding
- protein kinase binding
- ubiquitin-like ligase-substrate adaptor activity
- ubiquitin-like protein ligase binding
Cellular components
Protein domainsUniProt · Pfam · InterPro
- CDK5 regulatory subunit-associated protein 3
- CDK5 regulatory subunit-associated protein 3
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CDK5RAP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CDK5RAP3 as an antibody target. Whether an autoantibody or antibody against CDK5RAP3 could matter depends on whether native CDK5RAP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CDK5RAP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CDK5RAP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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