Seroatlas · Human Serome Atlas

MCOLN3

Mucolipin-3

Also known as: FLJ11006, MCLN3_HUMAN, TRP-ML3, TRPML3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TDD5
Gene
MCOLN3
Ensembl
ENSG00000055732
Chromosome
1
Canonical length
553 aa
Protein class
Predicted membrane proteins, Transporters, Voltage-gated ion channels
Quaternary structure
Homotetramer

OverviewNCBI Gene

This gene encodes one of members of the mucolipin cation channel proteins. Mutation studies of the highly similar protein in mice have shown that the protein is found in cochlea hair cells, and mutant mice show early-onset hearing loss and balance problems. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q8TDD5|MCOLN3
     1  MADPEVVVSS CSSHEEENRC NFNQQTSPSE ELLLEDQMRR KLKFFFMNPC EKFWARGRKP
    61  WKLAIQILKI AMVTIQLVLF GLSNQMVVAF KEENTIAFKH LFLKGYMDRM DDTYAVYTQS
   121  DVYDQLIFAV NQYLQLYNVS VGNHAYENKG TKQSAMAICQ HFYKRGNIYP GNDTFDIDPE
   181  IETECFFVEP DEPFHIGTPA ENKLNLTLDF HRLLTVELQF KLKAINLQTV RHQELPDCYD
   241  FTLTITFDNK AHSGRIKISL DNDISIRECK DWHVSGSIQK NTHYMMIFDA FVILTCLVSL
   301  ILCIRSVIRG LQLQQEFVNF FLLHYKKEVS VSDQMEFVNG WYIMIIISDI LTIIGSILKM
   361  EIQAKSLTSY DVCSILLGTS TMLVWLGVIR YLGFFAKYNL LILTLQAALP NVIRFCCCAA
   421  MIYLGYCFCG WIVLGPYHDK FRSLNMVSEC LFSLINGDDM FATFAKMQQK SYLVWLFSRI
   481  YLYSFISLFI YMILSLFIAL ITDTYETIKQ YQQDGFPETE LRTFISECKD LPNSGKYRLE
   541  DDPPVSLFCC CKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MCOLN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
6
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
41 nTPM

Expression across tissuesHPA

Tissue

  • adrenal gland: 41 nTPM
  • parathyroid gland: 33 nTPM
  • epididymis: 13 nTPM
  • pancreas: 7 nTPM
  • pituitary gland: 6.5 nTPM
  • endometrium: 5.4 nTPM

Single-cell type

  • adrenal cortex cells: 433 nCPM
  • melanocytes: 281 nCPM
  • gonadotrophs: 259 nCPM
  • pituitary stem cells: 103 nCPM
  • corticotrophs: 97 nCPM
  • neuroendocrine cells: 89 nCPM

Immune cell

  • memory CD4 T-cell: 0.6 nTPM
  • naive CD4 T-cell: 0.2 nTPM
  • memory CD8 T-cell: 0.1 nTPM
  • total PBMC: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM

Brain region

  • cerebral cortex: 8.3 nTPM
  • choroid plexus: 7.4 nTPM
  • hippocampal formation: 7.4 nTPM
  • amygdala: 1.5 nTPM
  • thalamus: 1.2 nTPM
  • basal ganglia: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.94
gnomAD pLI
0
gnomAD missense Z
0.62
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MCOLN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MCOLN3 as an antibody target. Whether an autoantibody or antibody against MCOLN3 could matter depends on whether native MCOLN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MCOLN3 is annotated at the cell surface, where native MCOLN3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MCOLN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MCOLN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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