Seroatlas · Human Serome Atlas

BNIP3

BCL2/adenovirus E1B 19 kDa protein-interacting protein 3

Also known as: BNIP3_HUMAN, HABON, Nip3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q12983
Gene: BNIP3
Ensembl: ENSG00000176171
Chromosome: 10
Canonical length: 194 aa
Protein class: Cancer-related genes, Predicted membrane proteins, Transporters
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014]

Canonical amino-acid sequenceUniProt

194 residues, UniProt reviewed canonical sequence.

>Q12983|BNIP3
     1  MSQNGAPGMQ EESLQGSWVE LHFSNNGNGG SVPASVSIYN GDMEKILLDA QHESGRSSSK
    61  SSHCDSPPRS QTPQDTNRAS ETDTHSIGEK NSSQSEEDDI ERRKEVESIL KKNSDWIWDW
   121  SSRPENIPPK EFLFKHPKRT ATLSMRNTSV MKKGGIFSAE FLKVFLPSLL LSHLLAIGLG
   181  IYIGRRLTTS TSTF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BNIP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 530 nTPM

Expression across tissuesHPA

Tissue

pancreas: 530 nTPM
skeletal muscle: 334 nTPM
liver: 222 nTPM
tongue: 163 nTPM
heart muscle: 145 nTPM
cerebral cortex: 144 nTPM

Single-cell type

esophageal apical cells: 1,326 nCPM
pancreatic acinar cells: 920 nCPM
extravillous trophoblasts: 673 nCPM
hepatocytes: 478 nCPM
migrating cytotrophoblasts: 314 nCPM
oocytes: 295 nCPM

Immune cell

naive CD4 T-cell: 48 nTPM
naive CD8 T-cell: 32 nTPM
T-reg: 30 nTPM
memory CD4 T-cell: 29 nTPM
MAIT T-cell: 22 nTPM
memory CD8 T-cell: 22 nTPM

Brain region

hippocampal formation: 170 nTPM
thalamus: 159 nTPM
pons: 159 nTPM
midbrain: 155 nTPM
cerebellum: 146 nTPM
medulla oblongata: 139 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.46
gnomAD pLI: 0
gnomAD missense Z: 0.83
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

endoplasmic reticulum-autophagosome adaptor activity
GTPase binding
identical protein binding
protein homodimerization activity
mitochondrion autophagosome adaptor activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BNIP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BNIP3 as an antibody target. Whether an autoantibody or antibody against BNIP3 could matter depends on whether native BNIP3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BNIP3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BNIP3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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