Seroatlas · Human Serome Atlas

GABARAPL1

Gamma-aminobutyric acid receptor-associated protein-like 1

Also known as: APG8L, ATG8B, ATG8L, GBRL1_HUMAN, gec1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0R8
Gene: GABARAPL1
Ensembl: ENSG00000139112
Chromosome: 12
Canonical length: 117 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles,Plasma membrane,Primary cilium,Basal body,Cytosol

OverviewNCBI Gene

Enables Tat protein binding activity; phospholipid binding activity; and ubiquitin protein ligase binding activity. Predicted to be involved in cellular response to nitrogen starvation and macroautophagy. Located in several cellular components, including autophagosome; ciliary basal body; and mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>Q9H0R8|GABARAPL1
     1  MKFQYKEDHP FEYRKKEGEK IRKKYPDRVP VIVEKAPKAR VPDLDKRKYL VPSDLTVGQF
    61  YFLIRKRIHL RPEDALFFFV NNTIPPTSAT MGQLYEDNHE EDYFLYVAYS DESVYGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GABARAPL1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 377 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 377 nTPM
heart muscle: 319 nTPM
cerebral cortex: 305 nTPM
kidney: 303 nTPM
retina: 303 nTPM
choroid plexus: 278 nTPM

Single-cell type

syncytiotrophoblasts: 1,338 nCPM
cytotrophoblasts: 381 nCPM
early spermatids: 323 nCPM
neutrophils: 317 nCPM
epididymal clear cells: 253 nCPM
parietal cells: 246 nCPM

Immune cell

neutrophil: 62 nTPM
basophil: 54 nTPM
eosinophil: 43 nTPM
gdT-cell: 27 nTPM
NK-cell: 23 nTPM
memory CD8 T-cell: 16 nTPM

Brain region

cerebral cortex: 476 nTPM
hypothalamus: 363 nTPM
pons: 335 nTPM
medulla oblongata: 315 nTPM
white matter: 312 nTPM
basal ganglia: 297 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.5
gnomAD pLI: 0.84
gnomAD missense Z: 1.19
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GABARAPL1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GABARAPL1 as an antibody target. Whether an autoantibody or antibody against GABARAPL1 could matter depends on whether native GABARAPL1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GABARAPL1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GABARAPL1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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