Seroatlas · Human Serome Atlas

MAPK15

Mitogen-activated protein kinase 15

Also known as: ERK7, ERK8, MK15_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8TD08
Gene
MAPK15
Ensembl
ENSG00000181085
Chromosome
8
Canonical length
544 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Vesicles,Cell Junctions,Cytosol

OverviewNCBI Gene

Enables MAP kinase activity and chromatin binding activity. Involved in several processes, including dopamine uptake; protein localization to ciliary transition zone; and regulation of organelle organization. Located in several cellular components, including Golgi apparatus; autophagosome; and microtubule organizing center. Biomarker of breast cancer. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

544 residues, UniProt reviewed canonical sequence.

>Q8TD08|MAPK15
     1  MCTVVDPRIV RRYLLRRQLG QGAYGIVWKA VDRRTGEVVA IKKIFDAFRD KTDAQRTFRE
    61  ITLLQEFGDH PNIISLLDVI RAENDRDIYL VFEFMDTDLN AVIRKGGLLQ DVHVRSIFYQ
   121  LLRATRFLHS GHVVHRDQKP SNVLLDANCT VKLCDFGLAR SLGDLPEGPE DQAVTEYVAT
   181  RWYRAPEVLL SSHRYTLGVD MWSLGCILGE MLRGRPLFPG TSTLHQLELI LETIPPPSEE
   241  DLLALGSGCR ASVLHQLGSR PRQTLDALLP PDTSPEALDL LRRLLVFAPD KRLSATQALQ
   301  HPYVQRFHCP SDEWAREADV RPRAHEGVQL SVPEYRSRVY QMILECGGSS GTSREKGPEG
   361  VSPSQAHLHK PRADPQLPSR TPVQGPRPRP QSSPGHDPAE HESPRAAKNV PRQNSAPLLQ
   421  TALLGNGERP PGAKEAPPLT LSLVKPSGRG AAPSLTSQAA AQVANQALIR GDWNRGGGVR
   481  VASVQQVPPR LPPEARPGRR MFSTSALQGA QGGARALLGG YSQAYGTVCH SALGHLPLLE
   541  GHHV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPK15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
71 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 71 nTPM
  • fallopian tube: 36 nTPM
  • thyroid gland: 16 nTPM
  • lung: 13 nTPM
  • testis: 11 nTPM
  • kidney: 11 nTPM

Single-cell type

  • ependymal cells: 134 nCPM
  • choroid plexus epithelial cells: 106 nCPM
  • fallopian tube ciliated cells: 19 nCPM
  • endometrial ciliated cells: 12 nCPM
  • respiratory ciliated cells: 7.2 nCPM
  • epididymal efferent duct ciliated cells: 7.1 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 112 nTPM
  • midbrain: 29 nTPM
  • medulla oblongata: 21 nTPM
  • pons: 13 nTPM
  • spinal cord: 12 nTPM
  • hypothalamus: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.51
gnomAD pLI
0
gnomAD missense Z
-1.35
DepMap mean gene effect
-0.17
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPK15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPK15 as an antibody target. Whether an autoantibody or antibody against MAPK15 could matter depends on whether native MAPK15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPK15 is annotated at the cell surface, where native MAPK15 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label MAPK15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAPK15. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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