Seroatlas · Human Serome Atlas

STBD1

Starch-binding domain-containing protein 1

Also known as: FLJ41801, GENX-3414, STBD1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95210
Gene: STBD1
Ensembl: ENSG00000118804
Chromosome: 4
Canonical length: 358 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Enables enzyme binding activity and glycogen binding activity. Involved in glycophagy and intracellular transport. Located in T-tubule; endoplasmic reticulum; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

358 residues, UniProt reviewed canonical sequence.

>O95210|STBD1
     1  MGAVWSALLV GGGLAGALFV WLLRGGPGDT GKDGDAEQEK DAPLGGAAIP GGHQSGSSGL
    61  SPGPSGQELV TKPEHLQESN GHLISKTKDL GKLQAASWRL QNPSREVCDN SREHVPSGQF
   121  PDTEAPATSE TSNSRSYSEV SRNESLESPM GEWGFQKGQE ISAKAATCFA EKLPSSNLLK
   181  NRAKEEMSLS DLNSQDRVDH EEWEMVPRHS SWGDVGVGGS LKAPVLNLNQ GMDNGRSTLV
   241  EARGQQVHGK MERVAVMPAG SQQVSVRFQV HYVTSTDVQF IAVTGDHECL GRWNTYIPLH
   301  YNKDGFWSHS IFLPADTVVE WKFVLVENGG VTRWEECSNR FLETGHEDKV VHAWWGIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STBD1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 233 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 233 nTPM
tongue: 144 nTPM
liver: 122 nTPM
adipose tissue: 103 nTPM
heart muscle: 53 nTPM
small intestine: 29 nTPM

Single-cell type

enterocytes: 15 nCPM
colonocytes: 7.1 nCPM
urothelial cells: 5 nCPM
fallopian tube ciliated cells: 4.5 nCPM
other brain neurons: 3.8 nCPM
goblet cells: 3.5 nCPM

Immune cell

eosinophil: 5.7 nTPM
NK-cell: 4.4 nTPM
intermediate monocyte: 3.1 nTPM
classical monocyte: 2.6 nTPM
myeloid DC: 2.5 nTPM
memory CD4 T-cell: 2.4 nTPM

Brain region

hypothalamus: 9.4 nTPM
medulla oblongata: 8.7 nTPM
pons: 7.9 nTPM
spinal cord: 6.5 nTPM
thalamus: 6.3 nTPM
white matter: 6.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

DepMap mean gene effect: 0.08
DepMap dependency class: none

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Carbohydrate binding module family 20
Immunoglobulin-like fold
Carbohydrate-binding-like fold
Starch binding domain
Starch-binding domain-containing protein 1, CBM20 domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STBD1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STBD1 as an antibody target. Whether an autoantibody or antibody against STBD1 could matter depends on whether native STBD1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STBD1 is annotated at the cell surface, where native STBD1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label STBD1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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