Seroatlas · Human Serome Atlas

NSMAF

Protein FAN

Also known as: FAN, FAN_HUMAN, GRAMD5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q92636
Gene: NSMAF
Ensembl: ENSG00000035681
Chromosome: 8
Canonical length: 917 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

Canonical amino-acid sequenceUniProt

917 residues, UniProt reviewed canonical sequence.

>Q92636|NSMAF
     1  MAFIRKKQQE QQLQLYSKER FSLLLLNLEE YYFEQHRANH ILHKGSHHER KIRGSLKICS
    61  KSVIFEPDSI SQPIIKIPLR DCIKIGKHGE NGANRHFTKA KSGGISLIFS QVYFIKEHNV
   121  VAPYKIERGK MEYVFELDVP GKVEDVVETL LQLHRASCLD KLGDQTAMIT AILQSRLART
   181  SFDKNRFQNI SEKLHMECKA EMVTPLVTNP GHVCITDTNL YFQPLNGYPK PVVQITLQDV
   241  RRIYKRRHGL MPLGLEVFCT EDDLCSDIYL KFYEPQDRDD LYFYIATYLE HHVAEHTAES
   301  YMLQWQRGHL SNYQYLLHLN NLADRSCNDL SQYPVFPWII HDYSSSELDL SNPGTFRDLS
   361  KPVGALNKER LERLLTRYQE MPEPKFMYGS HYSSPGYVLF YLVRIAPEYM LCLQNGRFDN
   421  ADRMFNSIAE TWKNCLDGAT DFKELIPEFY GDDVSFLVNS LKLDLGKRQG GQMVDDVELP
   481  PWASSPEDFL QKSKDALESN YVSEHLHEWI DLIFGYKQKG SDAVGAHNVF HPLTYEGGVD
   541  LNSIQDPDEK VAMLTQILEF GQTPKQLFVT PHPRRITPKF KSLSQTSSYN ASMADSPGEE
   601  SFEDLTEESK TLAWNNITKL QLHEHYKIHK EAVTGITVSR NGSSVFTTSQ DSTLKMFSKE
   661  SKMLQRSISF SNMALSSCLL LPGDATVITS SWDNNVYFYS IAFGRRQDTL MGHDDAVSKI
   721  CWHDNRLYSA SWDSTVKVWS GVPAEMPGTK RHHFDLLAEL EHDVSVDTIS LNAASTLLVS
   781  GTKEGTVNIW DLTTATLMHQ IPCHSGIVCD TAFSPDSRHV LSTGTDGCLN VIDVQTGMLI
   841  SSMTSDEPQR CFVWDGNSVL SGSQSGELLV WDLLGAKISE RIQGHTGAVT CIWMNEQCSS
   901  IITGGEDRQI IFWKLQY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NSMAF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

thymus: 33 nTPM
tonsil: 21 nTPM
lymph node: 20 nTPM
skin: 18 nTPM
skeletal muscle: 17 nTPM
parathyroid gland: 17 nTPM

Single-cell type

neutrophils: 290 nCPM
brain inhibitory neurons: 140 nCPM
cdc: 134 nCPM
hematopoietic stem cells: 127 nCPM
monocytes: 127 nCPM
oligodendrocyte progenitor cells: 123 nCPM

Immune cell

neutrophil: 15 nTPM
myeloid DC: 14 nTPM
T-reg: 8.6 nTPM
basophil: 8.3 nTPM
classical monocyte: 7.1 nTPM
memory CD8 T-cell: 6.5 nTPM

Brain region

thalamus: 16 nTPM
white matter: 14 nTPM
choroid plexus: 13 nTPM
medulla oblongata: 13 nTPM
basal ganglia: 13 nTPM
pons: 13 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about NSMAF.

Disease | ImmuneIEDB

Conditions an epitope on NSMAF was assayed in.

multiple sclerosis B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0
gnomAD missense Z: 1.45
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

BEACH domain
WD40 repeat
GRAM domain
PH-like domain superfamily
WD40/YVTN repeat-like-containing domain superfamily
PH-BEACH domain
WD40-repeat-containing domain superfamily
BEACH domain superfamily
BEACH Domain-Containing
WD domain, G-beta repeat
Beige/BEACH domain
GRAM domain
FAN-like, N-terminal PH domain
FAN protein N-terminal PH domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NSMAF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NSMAF as an antibody target. Whether an autoantibody or antibody against NSMAF could matter depends on whether native NSMAF is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NSMAF is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NSMAF as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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