Seroatlas · Human Serome Atlas

TAX1BP1

Tax1-binding protein 1

Also known as: CALCOCO3, TAXB1_HUMAN, TXBP151

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86VP1
Gene: TAX1BP1
Ensembl: ENSG00000106052
Chromosome: 7
Canonical length: 789 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

This gene encodes a HTLV-1 tax1 binding protein. The encoded protein interacts with TNFAIP3, and inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degradation of this protein by caspase-3-like family proteins is associated with apoptosis induced by TNF. This protein may also have a role in the inhibition of inflammatory signaling pathways. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

789 residues, UniProt reviewed canonical sequence.

>Q86VP1|TAX1BP1
     1  MTSFQEVPLQ TSNFAHVIFQ NVAKSYLPNA HLECHYTLTP YIHPHPKDWV GIFKVGWSTA
    61  RDYYTFLWSP MPEHYVEGST VNCVLAFQGY YLPNDDGEFY QFCYVTHKGE IRGASTPFQF
   121  RASSPVEELL TMEDEGNSDM LVVTTKAGLL ELKIEKTMKE KEELLKLIAV LEKETAQLRE
   181  QVGRMERELN HEKERCDQLQ AEQKGLTEVT QSLKMENEEF KKRFSDATSK AHQLEEDIVS
   241  VTHKAIEKET ELDSLKDKLK KAQHEREQLE CQLKTEKDEK ELYKVHLKNT EIENTKLMSE
   301  VQTLKNLDGN KESVITHFKE EIGRLQLCLA EKENLQRTFL LTTSSKEDTC FLKEQLRKAE
   361  EQVQATRQEV VFLAKELSDA VNVRDRTMAD LHTARLENEK VKKQLADAVA ELKLNAMKKD
   421  QDKTDTLEHE LRREVEDLKL RLQMAADHYK EKFKECQRLQ KQINKLSDQS ANNNNVFTKK
   481  TGNQQKVNDA SVNTDPATSA STVDVKPSPS AAEADFDIVT KGQVCEMTKE IADKTEKYNK
   541  CKQLLQDEKA KCNKYADELA KMELKWKEQV KIAENVKLEL AEVQDNYKEL KRSLENPAER
   601  KMEGQNSQSP QCFKTCSEQN GYVLTLSNAQ PVLQYGNPYA SQETRDGADG AFYPDEIQRP
   661  PVRVPSWGLE DNVVCSQPAR NFSRPDGLED SEDSKEDENV PTAPDPPSQH LRGHGTGFCF
   721  DSSFDVHKKC PLCELMFPPN YDQSKFEEHV ESHWKVCPMC SEQFPPDYDQ QVFERHVQTH
   781  FDQNVLNFD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAX1BP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.51
Highest tissue expression: 115 nTPM

Expression across tissuesHPA

Tissue

heart muscle: 115 nTPM
parathyroid gland: 115 nTPM
retina: 113 nTPM
esophagus: 103 nTPM
bone marrow: 100 nTPM
choroid plexus: 99 nTPM

Single-cell type

esophageal apical cells: 2,243 nCPM
syncytiotrophoblasts: 1,083 nCPM
neutrophils: 846 nCPM
retinal pigment epithelial cells: 729 nCPM
breast lactating cells: 640 nCPM
fallopian tube ciliated cells: 634 nCPM

Immune cell

eosinophil: 213 nTPM
neutrophil: 164 nTPM
basophil: 158 nTPM
T-reg: 119 nTPM
non-classical monocyte: 117 nTPM
intermediate monocyte: 101 nTPM

Brain region

choroid plexus: 116 nTPM
hypothalamus: 103 nTPM
cerebral cortex: 101 nTPM
thalamus: 98 nTPM
white matter: 97 nTPM
cerebellum: 96 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about TAX1BP1.

Disease | ImmuneIEDB

Conditions an epitope on TAX1BP1 was assayed in.

neuromyelitis optica B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.65
gnomAD pLI: 0
gnomAD missense Z: 1.26
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 12% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAX1BP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAX1BP1 as an antibody target. Whether an autoantibody or antibody against TAX1BP1 could matter depends on whether native TAX1BP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAX1BP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAX1BP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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