Seroatlas · Human Serome Atlas

RABGAP1

Rab GTPase-activating protein 1

Also known as: GAPCenA, RBGP1_HUMAN, TBC1D11

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3P9
Gene: RABGAP1
Ensembl: ENSG00000011454
Chromosome: 9
Canonical length: 1069 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables GTPase activator activity and small GTPase binding activity. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1069 residues, UniProt reviewed canonical sequence.

>Q9Y3P9|RABGAP1
     1  MDDKASVGKI SVSSDSVSTL NSEDFVLVSR QGDETPSTNN GSDDEKTGLK IVGNGSEQQL
    61  QKELADVLMD PPMDDQPGEK ELVKRSQLDG EGDGPLSNQL SASSTINPVP LVGLQKPEMS
   121  LPVKPGQGDS EASSPFTPVA DEDSVVFSKL TYLGCASVNA PRSEVEALRM MSILRSQCQI
   181  SLDVTLSVPN VSEGIVRLLD PQTNTEIANY PIYKILFCVR GHDGTPESDC FAFTESHYNA
   241  ELFRIHVFRC EIQEAVSRIL YSFATAFRRS AKQTPLSATA APQTPDSDIF TFSVSLEIKE
   301  DDGKGYFSAV PKDKDRQCFK LRQGIDKKIV IYVQQTTNKE LAIERCFGLL LSPGKDVRNS
   361  DMHLLDLESM GKSSDGKSYV ITGSWNPKSP HFQVVNEETP KDKVLFMTTA VDLVITEVQE
   421  PVRFLLETKV RVCSPNERLF WPFSKRSTTE NFFLKLKQIK QRERKNNTDT LYEVVCLESE
   481  SERERRKTTA SPSVRLPQSG SQSSVIPSPP EDDEEEDNDE PLLSGSGDVS KECAEKILET
   541  WGELLSKWHL NLNVRPKQLS SLVRNGVPEA LRGEVWQLLA GCHNNDHLVE KYRILITKES
   601  PQDSAITRDI NRTFPAHDYF KDTGGDGQDS LYKICKAYSV YDEEIGYCQG QSFLAAVLLL
   661  HMPEEQAFSV LVKIMFDYGL RELFKQNFED LHCKFYQLER LMQEYIPDLY NHFLDISLEA
   721  HMYASQWFLT LFTAKFPLYM VFHIIDLLLC EGISVIFNVA LGLLKTSKDD LLLTDFEGAL
   781  KFFRVQLPKR YRSEENAKKL MELACNMKIS QKKLKKYEKE YHTMREQQAQ QEDPIERFER
   841  ENRRLQEANM RLEQENDDLA HELVTSKIAL RKDLDNAEEK ADALNKELLM TKQKLIDAEE
   901  EKRRLEEESA QLKEMCRREL DKAESEIKKN SSIIGDYKQI CSQLSERLEK QQTANKVEIE
   961  KIRQKVDDCE RCREFFNKEG RVKGISSTKE VLDEDTDEEK ETLKNQLREM ELELAQTKLQ
  1021  LVEAECKIQD LEHHLGLALN EVQAAKKTWF NRTLSSIKTA TGVQGKETC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RABGAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

blood vessel: 52 nTPM
colon: 37 nTPM
thyroid gland: 37 nTPM
skeletal muscle: 32 nTPM
esophagus: 30 nTPM
smooth muscle: 30 nTPM

Single-cell type

pituicytes/fscs: 429 nCPM
sertoli cells: 404 nCPM
hematopoietic stem cells: 360 nCPM
prostatic glandular cells: 290 nCPM
vascular smooth muscle cells: 252 nCPM
pituitary stem cells: 250 nCPM

Immune cell

basophil: 3.4 nTPM
intermediate monocyte: 2.1 nTPM
neutrophil: 2.1 nTPM
eosinophil: 1.8 nTPM
naive CD4 T-cell: 1.6 nTPM
plasmacytoid DC: 1.5 nTPM

Brain region

midbrain: 67 nTPM
white matter: 64 nTPM
cerebral cortex: 63 nTPM
basal ganglia: 62 nTPM
pons: 62 nTPM
thalamus: 61 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about RABGAP1.

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 130 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder, RABGAP1-related

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.08
gnomAD pLI: 1
gnomAD missense Z: 2.96
DepMap mean gene effect: 0.07
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of GTPase activity

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RABGAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RABGAP1 as an antibody target. Whether an autoantibody or antibody against RABGAP1 could matter depends on whether native RABGAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RABGAP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RABGAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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