Seroatlas · Human Serome Atlas

NUDCD3

NudC domain-containing protein 3

Also known as: KIAA1068, NUDC3_HUMAN, NudCL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IVD9
Gene: NUDCD3
Ensembl: ENSG00000015676
Chromosome: 7
Canonical length: 361 aa
Protein class: Predicted intracellular proteins
Subcellular location: Plasma membrane,Primary cilium,Primary cilium tip,Cytosol,Principal piece

OverviewNCBI Gene

The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

361 residues, UniProt reviewed canonical sequence.

>Q8IVD9|NUDCD3
     1  METGAAELYD QALLGILQHV GNVQDFLRVL FGFLYRKTDF YRLLRHPSDR MGFPPGAAQA
    61  LVLQVFKTFD HMARQDDEKR RQELEEKIRR KEEEEAKTVS AAAAEKEPVP VPVQEIEIDS
   121  TTELDGHQEV EKVQPPGPVK EMAHGSQEAE APGAVAGAAE VPREPPILPR IQEQFQKNPD
   181  SYNGAVRENY TWSQDYTDLE VRVPVPKHVV KGKQVSVALS SSSIRVAMLE ENGERVLMEG
   241  KLTHKINTES SLWSLEPGKC VLVNLSKVGE YWWNAILEGE EPIDIDKINK ERSMATVDEE
   301  EQAVLDRLTF DYHQKLQGKP QSHELKVHEM LKKGWDAEGS PFRGQRFDPA MFNISPGAVQ
   361  F

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDCD3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 11 nTPM
cerebral cortex: 10 nTPM
skeletal muscle: 8.7 nTPM
amygdala: 8.3 nTPM
hippocampal formation: 8.1 nTPM
heart muscle: 7.7 nTPM

Single-cell type

late primary spermatocytes: 197 nCPM
pituitary stem cells: 151 nCPM
choroid plexus epithelial cells: 117 nCPM
pituicytes/fscs: 116 nCPM
lactotrophs: 109 nCPM
late spermatids: 109 nCPM

Immune cell

MAIT T-cell: 1.1 nTPM
gdT-cell: 1 nTPM
memory B-cell: 1 nTPM
naive B-cell: 1 nTPM
non-classical monocyte: 1 nTPM
T-reg: 1 nTPM

Brain region

basal ganglia: 29 nTPM
cerebral cortex: 25 nTPM
amygdala: 23 nTPM
hippocampal formation: 23 nTPM
white matter: 22 nTPM
midbrain: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.45
gnomAD missense Z: 0.85
DepMap mean gene effect: -0.6
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 15% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

unfolded protein binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

CS domain
HSP20-like chaperone
NudC N-terminal domain
NudC family
CS domain
N-terminal conserved domain of Nudc.
NudC domain-containing protein 3, p23 domain

KeywordsUniProt

Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of NUDCD3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDCD3 as an antibody target. Whether an autoantibody or antibody against NUDCD3 could matter depends on whether native NUDCD3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDCD3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDCD3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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