Seroatlas · Human Serome Atlas

DNAJC11

DnaJ homolog subfamily C member 11

Also known as: DJC11_HUMAN, FLJ10737

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NVH1
Gene
DNAJC11
Ensembl
ENSG00000007923
Chromosome
1
Canonical length
559 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Involved in cristae formation. Located in MICOS complex; SAM complex; and nuclear speck. Part of MIB complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

559 residues, UniProt reviewed canonical sequence.

>Q9NVH1|DNAJC11
     1  MATALSEEEL DNEDYYSLLN VRREASSEEL KAAYRRLCML YHPDKHRDPE LKSQAERLFN
    61  LVHQAYEVLS DPQTRAIYDI YGKRGLEMEG WEVVERRRTP AEIREEFERL QREREERRLQ
   121  QRTNPKGTIS VGVDATDLFD RYDEEYEDVS GSSFPQIEIN KMHISQSIEA PLTATDTAIL
   181  SGSLSTQNGN GGGSINFALR RVTSAKGWGE LEFGAGDLQG PLFGLKLFRN LTPRCFVTTN
   241  CALQFSSRGI RPGLTTVLAR NLDKNTVGYL QWRWGIQSAM NTSIVRDTKT SHFTVALQLG
   301  IPHSFALISY QHKFQDDDQT RVKGSLKAGF FGTVVEYGAE RKISRHSVLG AAVSVGVPQG
   361  VSLKVKLNRA SQTYFFPIHL TDQLLPSAMF YATVGPLVVY FAMHRLIIKP YLRAQKEKEL
   421  EKQRESAATD VLQKKQEAES AVRLMQESVR RIIEAEESRM GLIIVNAWYG KFVNDKSRKS
   481  EKVKVIDVTV PLQCLVKDSK LILTEASKAG LPGFYDPCVG EEKNLKVLYQ FRGVLHQVMV
   541  LDSEALRIPK QSHRIDTDG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DNAJC11 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • kidney: 40 nTPM
  • skeletal muscle: 33 nTPM
  • tongue: 32 nTPM
  • heart muscle: 31 nTPM
  • rectum: 23 nTPM
  • colon: 23 nTPM

Single-cell type

  • distal convoluted tubule cells: 146 nCPM
  • loop of henle epithelial cells: 146 nCPM
  • myonuclei: 115 nCPM
  • proximal tubule cells: 112 nCPM
  • retinal ganglion cells: 97 nCPM
  • renal connecting tubule cells: 95 nCPM

Immune cell

  • non-classical monocyte: 14 nTPM
  • intermediate monocyte: 13 nTPM
  • myeloid DC: 12 nTPM
  • basophil: 9.7 nTPM
  • NK-cell: 9.7 nTPM
  • classical monocyte: 9.2 nTPM

Brain region

  • cerebral cortex: 30 nTPM
  • thalamus: 24 nTPM
  • medulla oblongata: 22 nTPM
  • pons: 22 nTPM
  • hippocampal formation: 21 nTPM
  • midbrain: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
gnomAD missense Z
1.85
DepMap mean gene effect
-0.63
DepMap dependency class
common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DNAJC11 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DNAJC11 as an antibody target. Whether an autoantibody or antibody against DNAJC11 could matter depends on whether native DNAJC11 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DNAJC11 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DNAJC11 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/DNAJC11. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...