FKBP-type peptidyl-prolyl cis-trans isomerase domain
IPR001179
Definition
FKBP-type peptidylprolyl isomerases ([ec:5.2.1.8]) in vertebrates, are receptors for the two immunosuppressants, FK506 and rapamycin. The drugs inhibit T cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. Peptidylprolyl isomerases accelerate protein folding by catalysing the cis-trans isomerisation of proline imidic peptide bonds in oligopeptides. These proteins are found in a variety of organisms PMID:27664121. This entry represents a domain found in FKBP-type peptidylprolyl isomerases.
17 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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