Seroatlas · Human Serome Atlas

PTGES3

Prostaglandin E synthase 3

Also known as: cPGES, p23, TEBP, TEBP_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15185
Gene: PTGES3
Ensembl: ENSG00000110958
Chromosome: 12
Canonical length: 160 aa
Protein class: Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes an enzyme that converts prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2). This protein functions as a co-chaperone with heat shock protein 90 (HSP90), localizing to response elements in DNA and disrupting transcriptional activation complexes. Alternative splicing results in multiple transcript variants. There are multiple pseudogenes of this gene on several different chromosomes. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

160 residues, UniProt reviewed canonical sequence.

>Q15185|PTGES3
     1  MQPASAKWYD RRDYVFIEFC VEDSKDVNVN FEKSKLTFSC LGGSDNFKHL NEIDLFHCID
    61  PNDSKHKRTD RSILCCLRKG ESGQSWPRLT KERAKLNWLS VDFNNWKDWE DDSDEDMSNF
   121  DRFSEMMNNM GGDEDVDLPE VDGADDDSQD SDDEKMPDLE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PTGES3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 218 nTPM

Expression across tissuesHPA

Tissue

ovary: 218 nTPM
spinal cord: 209 nTPM
fallopian tube: 205 nTPM
liver: 204 nTPM
skeletal muscle: 201 nTPM
blood vessel: 185 nTPM

Single-cell type

extravillous trophoblasts: 800 nCPM
oocytes: 764 nCPM
migrating cytotrophoblasts: 755 nCPM
syncytiotrophoblasts: 749 nCPM
epididymal efferent duct ciliated cells: 748 nCPM
fallopian tube ciliated cells: 730 nCPM

Immune cell

non-classical monocyte: 348 nTPM
total PBMC: 316 nTPM
intermediate monocyte: 262 nTPM
T-reg: 192 nTPM
memory B-cell: 173 nTPM
MAIT T-cell: 173 nTPM

Brain region

white matter: 305 nTPM
medulla oblongata: 189 nTPM
hypothalamus: 188 nTPM
cerebellum: 187 nTPM
pons: 187 nTPM
midbrain: 181 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.23
gnomAD pLI: 0.99
gnomAD missense Z: 1.27
DepMap mean gene effect: -0.26
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PTGES3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PTGES3 as an antibody target. Whether an autoantibody or antibody against PTGES3 could matter depends on whether native PTGES3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PTGES3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PTGES3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...