MOS

Protein identityUniProt · HPA

UniProt accession

P00540

Gene

MOS

Ensembl

ENSG00000172680

Chromosome

8

Canonical length

346 aa

Protein class

Enzymes, Predicted intracellular proteins

OverviewNCBI Gene

MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

Canonical amino-acid sequenceUniProt

346 residues, UniProt reviewed canonical sequence.

>P00540|MOS
     1  MPSPLALRPY LRSEFSPSVD ARPCSSPSEL PAKLLLGATL PRAPRLPRRL AWCSIDWEQV
    61  CLLQRLGAGG FGSVYKATYR GVPVAIKQVN KCTKNRLASR RSFWAELNVA RLRHDNIVRV
   121  VAASTRTPAG SNSLGTIIME FGGNVTLHQV IYGAAGHPEG DAGEPHCRTG GQLSLGKCLK
   181  YSLDVVNGLL FLHSQSIVHL DLKPANILIS EQDVCKISDF GCSEKLEDLL CFQTPSYPLG
   241  GTYTHRAPEL LKGEGVTPKA DIYSFAITLW QMTTKQAPYS GERQHILYAV VAYDLRPSLS
   301  AAVFEDSLPG QRLGDVIQRC WRPSAAQRPS ARLLLVDLTS LKAELG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MOS can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

0.7 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about MOS.

Disease | AllUniProt

Conditions MOS is implicated in, by any mechanism.

• Oocyte/zygote/embryo maturation arrest 20 (OZEMA20) MIM:620383

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 60 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Oocyte/zygote/embryo maturation arrest 20

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.68

gnomAD pLI

0.59

gnomAD missense Z

1.15

DepMap mean gene effect

-0.14

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• chromatin organization
• establishment of meiotic spindle orientation
• MAPK cascade
• meiotic spindle organization
• oocyte maturation
• positive regulation of ERK1 and ERK2 cascade
• positive regulation of MAPK cascade
• regulation of meiotic nuclear division
• signal transduction
• negative regulation of metaphase/anaphase transition of meiotic cell cycle

Molecular functions

• ATP binding
• MAP kinase kinase kinase activity
• protein kinase activity
• protein serine kinase activity
• protein serine/threonine kinase activity

Cellular components

• cytoplasm

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Serine/Threonine Kinases and Pseudokinases
• Protein kinase domain

KeywordsUniProt

• ATP-binding
• Cytoplasm
• Kinase
• Nucleotide-binding
• Proto-oncogene
• Serine/threonine-protein kinase
• Transferase

InteractionsUniProt · HPA

Protein binding partners of MOS in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MAP2K1
• FKBP5
• HSP90AA1
• MTMR9
• PPP2R5A