Seroatlas · Human Serome Atlas

GLMN

Glomulin

Also known as: FAP48, FAP68, FKBPAP, GLML, GLMN_HUMAN, GVM, VMGLOM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q92990
Gene
GLMN
Ensembl
ENSG00000174842
Chromosome
1
Canonical length
594 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a phosphorylated protein that is a member of a Skp1-Cullin-F-box-like complex. The protein is essential for normal development of the vasculature and mutations in this gene have been associated with glomuvenous malformations, also called glomangiomas. Multiple splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

594 residues, UniProt reviewed canonical sequence.

>Q92990|GLMN
     1  MAVEELQSII KRCQILEEQD FKEEDFGLFQ LAGQRCIEEG HTDQLLEIIQ NEKNKVIIKN
    61  MGWNLVGPVV RCLLCKDKED SKRKVYFLIF DLLVKLCNPK ELLLGLLELI EEPSGKQISQ
   121  SILLLLQPLQ TVIQKLHNKA YSIGLALSTL WNQLSLLPVP YSKEQIQMDD YGLCQCCKAL
   181  IEFTKPFVEE VIDNKENSLE NEKLKDELLK FCFKSLKCPL LTAQFFEQSE EGGNDPFRYF
   241  ASEIIGFLSA IGHPFPKMIF NHGRKKRTWN YLEFEEEENK QLADSMASLA YLVFVQGIHI
   301  DQLPMVLSPL YLLQFNMGHI EVFLQRTEES VISKGLELLE NSLLRIEDNS LLYQYLEIKS
   361  FLTVPQGLVK VMTLCPIETL RKKSLAMLQL YINKLDSQGK YTLFRCLLNT SNHSGVEAFI
   421  IQNIKNQIDM SLKRTRNNKW FTGPQLISLL DLVLFLPEGA ETDLLQNSDR IMASLNLLRY
   481  LVIKDNENDN QTGLWTELGN IENNFLKPLH IGLNMSKAHY EAEIKNSQEA QKSKDLCSIT
   541  VSGEEIPNMP PEMQLKVLHS ALFTFDLIES VLARVEELIE IKTKSTSEEN IGIK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLMN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
36 nTPM

Expression across tissuesHPA

Tissue

  • retina: 36 nTPM
  • cerebellum: 9.9 nTPM
  • skin: 8.8 nTPM
  • tonsil: 8.2 nTPM
  • thymus: 8 nTPM
  • cerebral cortex: 7.8 nTPM

Single-cell type

  • rod photoreceptor cells: 487 nCPM
  • cone photoreceptor cells: 387 nCPM
  • retinal ganglion cells: 174 nCPM
  • retinal amacrine cells: 157 nCPM
  • retinal bipolar cells: 141 nCPM
  • t-cells: 97 nCPM

Immune cell

  • NK-cell: 7.4 nTPM
  • MAIT T-cell: 5.5 nTPM
  • memory CD8 T-cell: 3.6 nTPM
  • naive CD8 T-cell: 3.2 nTPM
  • gdT-cell: 3 nTPM
  • memory CD4 T-cell: 3 nTPM

Brain region

  • cerebellum: 16 nTPM
  • cerebral cortex: 13 nTPM
  • choroid plexus: 11 nTPM
  • basal ganglia: 11 nTPM
  • white matter: 10 nTPM
  • hypothalamus: 8.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GLMN.

Disease | AllUniProt

Conditions GLMN is implicated in, by any mechanism.

Disease | GeneticClinVar

52 pathogenic / likely-pathogenic of 192 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.91
gnomAD pLI
0
gnomAD missense Z
0.95
DepMap mean gene effect
-0.26
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • YAP-binding/ALF4/Glomulin
  • Glomulin/ALF4
  • Uncharacterised protein family, YAP/Alf4/glomulin

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GLMN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLMN as an antibody target. Whether an autoantibody or antibody against GLMN could matter depends on whether native GLMN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLMN is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLMN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GLMN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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