Seroatlas · Human Serome Atlas

PHLPP2

PH domain leucine-rich repeat-containing protein phosphatase 2

Also known as: KIAA0931, PHLP2_HUMAN, PHLPPL, PPM3B

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZVD8
Gene: PHLPP2
Ensembl: ENSG00000040199
Chromosome: 16
Canonical length: 1323 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Cytokinetic bridge,Mitotic spindle,Primary cilium,Cytosol

OverviewNCBI Gene

Predicted to enable metal ion binding activity and phosphoprotein phosphatase activity. Predicted to be involved in intracellular signal transduction. Located in several cellular components, including cilium; intercellular bridge; and mitotic spindle. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1323 residues, UniProt reviewed canonical sequence.

>Q6ZVD8|PHLPP2
     1  MKRNGSRNCL NRRSRFGSRE RDWLREDVKR GCVYLYGADT TTATTTTTTS SSSSSSSSSS
    61  DLHLVLCTVE TPASEICAGE GRESLYLQLH GDLVRRLEPT ERPLQIVYDY LSRLGFDDPV
   121  RIQEEATNPD LGCMIRFYGE KPCHMDRLDR ILLSGIYNVR KGKTQLHKWA ERLVVLCGTC
   181  LIVSSVKDCQ TGKMHILPLV GGKIEEVKRR QYSLAFSSAG AQAQTYHVSF ETLAEYQRWQ
   241  RQASKVVSQR ISTVDLSCYS LEEVPEHLFY SQDITYLNLR HNFMQLERPG GLDTLYKFSQ
   301  LKGLNLSHNK LGLFPILLCE ISTLTELNLS CNGFHDLPSQ IGNLLNLQTL CLDGNFLTTL
   361  PEELGNLQQL SSLGISFNNF SQIPEVYEKL TMLDRVVMAG NCLEVLNLGV LNRMNHIKHV
   421  DLRMNHLKTM VIENLEGNKH ITHVDLRDNR LTDLDLSSLC SLEQLHCGRN QLRELTLSGF
   481  SLRTLYASSN RLTAVNVYPV PSLLTFLDLS RNLLECVPDW ACEAKKIEVL DVSYNLLTEV
   541  PVRILSSLSL RKLMLGHNHV QNLPTLVEHI PLEVLDLQHN ALTRLPDTLF SKALNLRYLN
   601  ASANSLESLP SACTGEESLS MLQLLYLTNN LLTDQCIPVL VGHLHLRILH LANNQLQTFP
   661  ASKLNKLEQL EELNLSGNKL KTIPTTIANC KRLHTLVAHS NNISIFPEIL QLPQIQFVDL
   721  SCNDLTEILI PEALPATLQD LDLTGNTNLV LEHKTLDIFS HITTLKIDQK PLPTTDSTVT
   781  STFWSHGLAE MAGQRNKLCV SALAMDSFAE GVGAVYGMFD GDRNEELPRL LQCTMADVLL
   841  EEVQQSTNDT VFMANTFLVS HRKLGMAGQK LGSSALLCYI RPDTADPASS FSLTVANVGT
   901  CQAVLCRGGK PVPLSKVFSL EQDPEEAQRV KDQKAIITED NKVNGVTCCT RMLGCTYLYP
   961  WILPKPHISS TPLTIQDELL ILGNKALWEH LSYTEAVNAV RHVQDPLAAA KKLCTLAQSY
  1021  GCQDNVGAMV VYLNIGEEGC TCEMNGLTLP GPVGFASTTT IKDAPKPATP SSSSGIASEF
  1081  SSEMSTSEVS SEVGSTASDE HNAGGLDTAL LPRPERRCSL HPTPTSGLFQ RQPSSATFSS
  1141  NQSDNGLDSD DDQPVEGVIT NGSKVEVEVD IHCCRGRDLE NSPPLIESSP TLCSEEHARG
  1201  SCFGIRRQNS VNSGMLLPMS KDRMELQKSP STSCLYGKKL SNGSIVPLED SLNLIEVATE
  1261  VPKRKTGYFA APTQMEPEDQ FVVPHDLEEE VKEQMKQHQD SRLEPEPHEE DRTEPPEEFD
  1321  TAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PHLPP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

retina: 30 nTPM
small intestine: 21 nTPM
rectum: 11 nTPM
colon: 11 nTPM
duodenum: 11 nTPM
cerebellum: 9.1 nTPM

Single-cell type

rod photoreceptor cells: 347 nCPM
cone photoreceptor cells: 323 nCPM
enterocytes: 286 nCPM
retinal pigment epithelial cells: 200 nCPM
colonocytes: 153 nCPM
pdcs: 143 nCPM

Immune cell

NK-cell: 0.8 nTPM
memory B-cell: 0.5 nTPM
plasmacytoid DC: 0.5 nTPM
memory CD8 T-cell: 0.3 nTPM
naive B-cell: 0.3 nTPM
T-reg: 0.3 nTPM

Brain region

cerebral cortex: 33 nTPM
basal ganglia: 32 nTPM
cerebellum: 29 nTPM
hippocampal formation: 28 nTPM
hypothalamus: 28 nTPM
amygdala: 27 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PHLPP2.

Disease | ImmuneIEDB

Conditions an epitope on PHLPP2 was assayed in.

colorectal adenocarcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0
gnomAD missense Z: -0.63
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PHLPP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PHLPP2 as an antibody target. Whether an autoantibody or antibody against PHLPP2 could matter depends on whether native PHLPP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PHLPP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PHLPP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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