Seroatlas · Human Serome Atlas

ALDH1B1

Aldehyde dehydrogenase X, mitochondrial

Also known as: AL1B1_HUMAN, ALDH5, ALDHX

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P30837
Gene: ALDH1B1
Ensembl: ENSG00000137124
Chromosome: 9
Canonical length: 517 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Mitochondria
Quaternary structure: Homotetramer

OverviewNCBI Gene

This protein belongs to the aldehyde dehydrogenases family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. This gene does not contain introns in the coding sequence. The variation of this locus may affect the development of alcohol-related problems. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

517 residues, UniProt reviewed canonical sequence.

>P30837|ALDH1B1
     1  MLRFLAPRLL SLQGRTARYS SAAALPSPIL NPDIPYNQLF INNEWQDAVS KKTFPTVNPT
    61  TGEVIGHVAE GDRADVDRAV KAAREAFRLG SPWRRMDASE RGRLLNRLAD LVERDRVYLA
   121  SLETLDNGKP FQESYALDLD EVIKVYRYFA GWADKWHGKT IPMDGQHFCF TRHEPVGVCG
   181  QIIPWNFPLV MQGWKLAPAL ATGNTVVMKV AEQTPLSALY LASLIKEAGF PPGVVNIITG
   241  YGPTAGAAIA QHVDVDKVAF TGSTEVGHLI QKAAGDSNLK RVTLELGGKS PSIVLADADM
   301  EHAVEQCHEA LFFNMGQCCC AGSRTFVEES IYNEFLERTV EKAKQRKVGN PFELDTQQGP
   361  QVDKEQFERV LGYIQLGQKE GAKLLCGGER FGERGFFIKP TVFGGVQDDM RIAKEEIFGP
   421  VQPLFKFKKI EEVVERANNT RYGLAAAVFT RDLDKAMYFT QALQAGTVWV NTYNIVTCHT
   481  PFGGFKESGN GRELGEDGLK AYTEVKTVTI KVPQKNS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ALDH1B1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.23
Highest tissue expression: 161 nTPM

Expression across tissuesHPA

Tissue

liver: 161 nTPM
blood vessel: 138 nTPM
smooth muscle: 120 nTPM
urinary bladder: 84 nTPM
colon: 58 nTPM
kidney: 55 nTPM

Single-cell type

smooth muscle cells: 184 nCPM
hepatocytes: 156 nCPM
enteric stem cells: 140 nCPM
paneth cells: 124 nCPM
cholangiocytes: 93 nCPM
extravillous trophoblasts: 61 nCPM

Immune cell

non-classical monocyte: 12 nTPM
MAIT T-cell: 9.5 nTPM
myeloid DC: 9.4 nTPM
intermediate monocyte: 9.2 nTPM
NK-cell: 8 nTPM
gdT-cell: 6.6 nTPM

Brain region

choroid plexus: 18 nTPM
hypothalamus: 15 nTPM
pons: 14 nTPM
cerebellum: 13 nTPM
white matter: 13 nTPM
thalamus: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.3
gnomAD pLI: 0
gnomAD missense Z: -0.23
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ALDH1B1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

FKBP5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ALDH1B1 as an antibody target. Whether an autoantibody or antibody against ALDH1B1 could matter depends on whether native ALDH1B1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ALDH1B1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ALDH1B1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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