Seroatlas · Human Serome Atlas

CDK15

Cyclin-dependent kinase 15

Also known as: ALS2CR7, CDK15_HUMAN, PFTAIRE2, PFTK2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96Q40
Gene: CDK15
Ensembl: ENSG00000138395
Chromosome: 2
Canonical length: 435 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus

OverviewNCBI Gene

Enables protein serine/threonine kinase activity. Predicted to be involved in regulation of cell cycle phase transition. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

435 residues, UniProt reviewed canonical sequence.

>Q96Q40|CDK15
     1  MGQELCAKTV QPGCSCYHCS EGGEAHSCRR SQPETTEAAF KLTDLKEASC SMTSFHPRGL
    61  QAARAQKFKS KRPRSNSDCF QEEDLRQGFQ WRKSLPFGAA SSYLNLEKLG EGSYATVYKG
   121  ISRINGQLVA LKVISMNAEE GVPFTAIREA SLLKGLKHAN IVLLHDIIHT KETLTFVFEY
   181  MHTDLAQYMS QHPGGLHPHN VRLFMFQLLR GLAYIHHQHV LHRDLKPQNL LISHLGELKL
   241  ADFGLARAKS IPSQTYSSEV VTLWYRPPDA LLGATEYSSE LDIWGAGCIF IEMFQGQPLF
   301  PGVSNILEQL EKIWEVLGVP TEDTWPGVSK LPNYNPEWFP LPTPRSLHVV WNRLGRVPEA
   361  EDLASQMLKG FPRDRVSAQE ALVHDYFSAL PSQLYQLPDE ESLFTVSGVR LKPEMCDLLA
   421  SYQKGHHPAQ FSKCW

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK15 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

epididymis: 14 nTPM
ovary: 4.7 nTPM
testis: 1.8 nTPM
gallbladder: 1.7 nTPM
blood vessel: 1.4 nTPM
lung: 1 nTPM

Single-cell type

mast cells: 392 nCPM
late spermatids: 78 nCPM
early spermatids: 35 nCPM
epididymal principal cells: 34 nCPM
ovarian stromal cells: 27 nCPM
late primary spermatocytes: 27 nCPM

Immune cell

eosinophil: 3.7 nTPM
basophil: 1.9 nTPM
classical monocyte: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 5.8 nTPM
hippocampal formation: 1.9 nTPM
cerebral cortex: 1.7 nTPM
medulla oblongata: 1.7 nTPM
pons: 1.6 nTPM
white matter: 1.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.35
gnomAD pLI: 0
gnomAD missense Z: 0
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

regulation of cell cycle phase transition

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDK15 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDK15 as an antibody target. Whether an autoantibody or antibody against CDK15 could matter depends on whether native CDK15 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDK15 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDK15 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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