Seroatlas · Human Serome Atlas

IRAK1

Interleukin-1 receptor-associated kinase 1

Also known as: IRAK, IRAK1_HUMAN, pelle

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51617
Gene: IRAK1
Ensembl: ENSG00000184216
Chromosome: X
Canonical length: 712 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

712 residues, UniProt reviewed canonical sequence.

>P51617|IRAK1
     1  MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV RDQTELRLCE
    61  RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT AWHPPAPLPS PGTTAPRPSS
   121  IPAPAEAEAW SPRKLPSSAS TFLSPAFPGS QTHSGPELGL VPSPASLWPP PPSPAPSSTK
   181  PGPESSVSLL QGARPFPFCW PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR
   241  LKENADLEWT AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL
   301  HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE RLTPKLGDFG
   361  LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR LAVDTDTFSF GVVVLETLAG
   421  QRAVKTHGAR TKYLKDLVEE EAEEAGVALR STQSTLQAGL AADAWAAPIA MQIYKKHLDP
   481  RPGPCPPELG LGLGQLACCC LHRRAKRRPP MTQVYERLEK LQAVVAGVPG HSEAASCIPP
   541  SPQENSYVSS TGRAHSGAAP WQPLAAPSGA SAQAAEQLQR GPNQPVESDE SLGGLSAALR
   601  SWHLTPSCPL DPAPLREAGC PQGDTAGESS WGSGPGSRPT AVEGLALGSS ASSSSEPPQI
   661  IINPARQKMV QKLALYEDGA LDSLQLLSSS SLPGLGLEQD RQGPEESDEF QS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IRAK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 89 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 89 nTPM
pancreas: 83 nTPM
esophagus: 68 nTPM
spleen: 68 nTPM
liver: 62 nTPM
adrenal gland: 60 nTPM

Single-cell type

monocytes: 90 nCPM
megakaryocytes: 87 nCPM
alveolar cells type 1: 66 nCPM
plasma cells: 66 nCPM
esophageal suprabasal cells: 59 nCPM
esophageal apical cells: 58 nCPM

Immune cell

intermediate monocyte: 3 nTPM
eosinophil: 2.9 nTPM
NK-cell: 2.3 nTPM
non-classical monocyte: 1.9 nTPM
memory B-cell: 1.8 nTPM
naive B-cell: 1.6 nTPM

Brain region

medulla oblongata: 65 nTPM
cerebral cortex: 58 nTPM
thalamus: 56 nTPM
pons: 49 nTPM
midbrain: 48 nTPM
spinal cord: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 0.99
gnomAD missense Z: 1.99
DepMap mean gene effect: 0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Death domain
Protein kinase domain
Serine/threonine-protein kinase, active site
Protein kinase-like domain superfamily
Death-like domain superfamily
Protein kinase, ATP binding site
Protein kinase domain
Death domain
Interleukin-1 receptor-associated kinase 1, death domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IRAK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IRAK1 as an antibody target. Whether an autoantibody or antibody against IRAK1 could matter depends on whether native IRAK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IRAK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IRAK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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