Seroatlas · Human Serome Atlas

CILK1

Serine/threonine-protein kinase ICK

Also known as: CILK1_HUMAN, ICK, KIAA0936, LCK2, MGC46090, MRK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UPZ9
Gene
CILK1
Ensembl
ENSG00000112144
Chromosome
6
Canonical length
632 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Golgi apparatus,Vesicles,Primary cilium,Primary cilium tip

OverviewNCBI Gene

Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

632 residues, UniProt reviewed canonical sequence.

>Q9UPZ9|CILK1
     1  MNRYTTIRQL GDGTYGSVLL GRSIESGELI AIKKMKRKFY SWEECMNLRE VKSLKKLNHA
    61  NVVKLKEVIR ENDHLYFIFE YMKENLYQLI KERNKLFPES AIRNIMYQIL QGLAFIHKHG
   121  FFHRDLKPEN LLCMGPELVK IADFGLAREI RSKPPYTDYV STRWYRAPEV LLRSTNYSSP
   181  IDVWAVGCIM AEVYTLRPLF PGASEIDTIF KICQVLGTPK KTDWPEGYQL SSAMNFRWPQ
   241  CVPNNLKTLI PNASSEAVQL LRDMLQWDPK KRPTASQALR YPYFQVGHPL GSTTQNLQDS
   301  EKPQKGILEK AGPPPYIKPV PPAQPPAKPH TRISSRQHQA SQPPLHLTYP YKAEVSRTDH
   361  PSHLQEDKPS PLLFPSLHNK HPQSKITAGL EHKNGEIKPK SRRRWGLISR STKDSDDWAD
   421  LDDLDFSPSL SRIDLKNKKR QSDDTLCRFE SVLDLKPSEP VGTGNSAPTQ TSYQRRDTPT
   481  LRSAAKQHYL KHSRYLPGIS IRNGILSNPG KEFIPPNPWS SSGLSGKSSG TMSVISKVNS
   541  VGSSSTSSSG LTGNYVPSFL KKEIGSAMQR VHLAPIPDPS PGYSSLKAMR PHPGRPFFHT
   601  QPRSTPGLIP RPPAAQPVHG RTDWASKYAS RR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CILK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
17 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 17 nTPM
  • adrenal gland: 17 nTPM
  • retina: 16 nTPM
  • stomach: 12 nTPM
  • placenta: 11 nTPM
  • spinal cord: 10 nTPM

Single-cell type

  • adrenal cortex cells: 117 nCPM
  • cone photoreceptor cells: 97 nCPM
  • oligodendrocytes: 97 nCPM
  • syncytiotrophoblasts: 80 nCPM
  • salivary acinar cells: 69 nCPM
  • conjunctival goblet cells: 67 nCPM

Immune cell

  • basophil: 2.8 nTPM
  • eosinophil: 2.2 nTPM
  • gdT-cell: 1.7 nTPM
  • T-reg: 1.7 nTPM
  • MAIT T-cell: 1.5 nTPM
  • naive B-cell: 1.5 nTPM

Brain region

  • thalamus: 33 nTPM
  • white matter: 27 nTPM
  • midbrain: 26 nTPM
  • basal ganglia: 24 nTPM
  • amygdala: 23 nTPM
  • medulla oblongata: 21 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CILK1.

Disease | AllUniProt

Conditions CILK1 is implicated in, by any mechanism.

Disease | GeneticClinVar

6 pathogenic / likely-pathogenic of 283 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CILK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CILK1 as an antibody target. Whether an autoantibody or antibody against CILK1 could matter depends on whether native CILK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CILK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CILK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CILK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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