Seroatlas · Human Serome Atlas

NUDC

Nuclear migration protein nudC

Also known as: NUDC_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y266
Gene: NUDC
Ensembl: ENSG00000090273
Chromosome: 1
Canonical length: 331 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a nuclear distribution protein that plays an essential role in mitosis and cytokinesis. The encoded protein is involved in spindle formation during mitosis and in microtubule organization during cytokinesis. Pseudogenes of this gene are found on chromosome 2. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

331 residues, UniProt reviewed canonical sequence.

>Q9Y266|NUDC
     1  MGGEQEEERF DGMLLAMAQQ HEGGVQELVN TFFSFLRRKT DFFIGGEEGM AEKLITQTFS
    61  HHNQLAQKTR REKRARQEAE RREKAERAAR LAKEAKSETS GPQIKELTDE EAERLQLEID
   121  QKKDAENHEA QLKNGSLDSP GKQDTEEDEE EDEKDKGKLK PNLGNGADLP NYRWTQTLSE
   181  LDLAVPFCVN FRLKGKDMVV DIQRRHLRVG LKGQPAIIDG ELYNEVKVEE SSWLIEDGKV
   241  VTVHLEKINK MEWWSRLVSS DPEINTKKIN PENSKLSDLD SETRSMVEKM MYDQRQKSMG
   301  LPTSDEQKKQ EILKKFMDQH PEMDFSKAKF N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NUDC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 158 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 158 nTPM
adrenal gland: 134 nTPM
cerebral cortex: 126 nTPM
skeletal muscle: 122 nTPM
amygdala: 113 nTPM
liver: 112 nTPM

Single-cell type

hepatocytes: 735 nCPM
fallopian tube ciliated cells: 734 nCPM
respiratory ciliated cells: 621 nCPM
epididymal efferent duct ciliated cells: 518 nCPM
endometrial ciliated cells: 487 nCPM
differentiating spermatogonia: 329 nCPM

Immune cell

naive B-cell: 187 nTPM
basophil: 185 nTPM
memory B-cell: 177 nTPM
total PBMC: 168 nTPM
T-reg: 164 nTPM
plasmacytoid DC: 164 nTPM

Brain region

cerebral cortex: 93 nTPM
choroid plexus: 88 nTPM
white matter: 88 nTPM
hypothalamus: 81 nTPM
cerebellum: 76 nTPM
pons: 72 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.38
gnomAD pLI: 0.89
gnomAD missense Z: 0.79
DepMap mean gene effect: -0.75
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NUDC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NUDC as an antibody target. Whether an autoantibody or antibody against NUDC could matter depends on whether native NUDC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NUDC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NUDC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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