Seroatlas · Human Serome Atlas

AHSA1

Activator of 90 kDa heat shock protein ATPase homolog 1

Also known as: Aha1, AHSA1_HUMAN, C14orf3, hAha1, p38

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O95433
Gene: AHSA1
Ensembl: ENSG00000100591
Chromosome: 14
Canonical length: 338 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Cytosol

OverviewNCBI Gene

Enables several functions, including ATPase activator activity; Hsp90 protein binding activity; and unfolded protein binding activity. Involved in maintenance of unfolded protein and positive regulation of ATP-dependent activity. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>O95433|AHSA1
     1  MAKWGEGDPR WIVEERADAT NVNNWHWTER DASNWSTDKL KTLFLAVQVQ NEEGKCEVTE
    61  VSKLDGEASI NNRKGKLIFF YEWSVKLNWT GTSKSGVQYK GHVEIPNLSD ENSVDEVEIS
   121  VSLAKDEPDT NLVALMKEEG VKLLREAMGI YISTLKTEFT QGMILPTMNG ESVDPVGQPA
   181  LKTEERKAKP APSKTQARPV GVKIPTCKIT LKETFLTSPE ELYRVFTTQE LVQAFTHAPA
   241  TLEADRGGKF HMVDGNVSGE FTDLVPEKHI VMKWRFKSWP EGHFATITLT FIDKNGETEL
   301  CMEGRGIPAP EEERTRQGWQ RYYFEGIKQT FGYGARLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AHSA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 135 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 135 nTPM
fallopian tube: 114 nTPM
heart muscle: 113 nTPM
choroid plexus: 113 nTPM
spinal cord: 112 nTPM
tongue: 111 nTPM

Single-cell type

fallopian tube ciliated cells: 241 nCPM
respiratory ciliated cells: 191 nCPM
cytotrophoblasts: 189 nCPM
migrating cytotrophoblasts: 187 nCPM
esophageal basal cells: 156 nCPM
syncytiotrophoblasts: 153 nCPM

Immune cell

non-classical monocyte: 93 nTPM
NK-cell: 89 nTPM
basophil: 83 nTPM
memory B-cell: 81 nTPM
T-reg: 77 nTPM
MAIT T-cell: 77 nTPM

Brain region

white matter: 100 nTPM
cerebral cortex: 82 nTPM
pons: 78 nTPM
thalamus: 74 nTPM
cerebellum: 74 nTPM
medulla oblongata: 73 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.15
gnomAD pLI: 1
gnomAD missense Z: 1.69
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AHSA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AHSA1 as an antibody target. Whether an autoantibody or antibody against AHSA1 could matter depends on whether native AHSA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AHSA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AHSA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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