Seroatlas · Human Serome Atlas

EIF2AK1

Eukaryotic translation initiation factor 2-alpha kinase 1

Also known as: E2AK1_HUMAN, HCR, hHRI, HRI, KIAA1369

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BQI3
Gene
EIF2AK1
Ensembl
ENSG00000086232
Chromosome
7
Canonical length
630 aa
Protein class
Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene acts at the level of translation initiation to downregulate protein synthesis in response to stress. The encoded protein is a kinase that can be inactivated by hemin. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Canonical amino-acid sequenceUniProt

630 residues, UniProt reviewed canonical sequence.

>Q9BQI3|EIF2AK1
     1  MQGGNSGVRK REEEGDGAGA VAAPPAIDFP AEGPDPEYDE SDVPAEIQVL KEPLQQPTFP
    61  FAVANQLLLV SLLEHLSHVH EPNPLRSRQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH
   121  NRAITHLMRS AKERVRQDPC EDISRIQKIR SREVALEAQT SRYLNEFEEL AILGKGGYGR
   181  VYKVRNKLDG QYYAIKKILI KGATKTVCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVI
   241  QPRADRAAIE LPSLEVLSDQ EEDREQCGVK NDESSSSSII FAEPTPEKEK RFGESDTENQ
   301  NNKSVKYTTN LVIRESGELE STLELQENGL AGLSASSIVE QQLPLRRNSH LEESFTSTEE
   361  SSEENVNFLG QTEAQYHLML HIQMQLCELS LWDWIVERNK RGREYVDESA CPYVMANVAT
   421  KIFQELVEGV FYIHNMGIVH RDLKPRNIFL HGPDQQVKIG DFGLACTDIL QKNTDWTNRN
   481  GKRTPTHTSR VGTCLYASPE QLEGSEYDAK SDMYSLGVVL LELFQPFGTE MERAEVLTGL
   541  RTGQLPESLR KRCPVQAKYI QHLTRRNSSQ RPSAIQLLQS ELFQNSGNVN LTLQMKIIEQ
   601  EKEIAELKKQ LNLLSQDKGV RDDGKDGGVG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EIF2AK1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
100 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 100 nTPM
  • parathyroid gland: 73 nTPM
  • liver: 61 nTPM
  • choroid plexus: 60 nTPM
  • placenta: 49 nTPM
  • stomach: 46 nTPM

Single-cell type

  • platelets: 1,349 nCPM
  • syncytiotrophoblasts: 521 nCPM
  • erythrocyte progenitors: 319 nCPM
  • cytotrophoblasts: 295 nCPM
  • erythrocytes: 270 nCPM
  • migrating cytotrophoblasts: 203 nCPM

Immune cell

  • eosinophil: 17 nTPM
  • memory B-cell: 12 nTPM
  • basophil: 11 nTPM
  • NK-cell: 10 nTPM
  • naive B-cell: 9.6 nTPM
  • memory CD8 T-cell: 9.3 nTPM

Brain region

  • choroid plexus: 53 nTPM
  • white matter: 48 nTPM
  • pons: 45 nTPM
  • hypothalamus: 44 nTPM
  • cerebellum: 43 nTPM
  • cerebral cortex: 43 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EIF2AK1.

Disease | AllUniProt

Conditions EIF2AK1 is implicated in, by any mechanism.

  • Leukoencephalopathy, motor delay, spasticity, and dysarthria syndrome (LEMSPAD) MIM:618878

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.71
gnomAD pLI
0
gnomAD missense Z
0.43
DepMap mean gene effect
0.04
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 16% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EIF2AK1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EIF2AK1 as an antibody target. Whether an autoantibody or antibody against EIF2AK1 could matter depends on whether native EIF2AK1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EIF2AK1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EIF2AK1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EIF2AK1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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