Seroatlas · Human Serome Atlas

CDC37L1

Hsp90 co-chaperone Cdc37-like 1

Also known as: CD37L_HUMAN, CDC37B, FLJ20639, HARC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7L3B6
Gene: CDC37L1
Ensembl: ENSG00000106993
Chromosome: 9
Canonical length: 337 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

CDC37L1 is a cytoplasmic phosphoprotein that exists in complex with HSP90 (HSPCA; MIM 140571) as well as several other proteins involved in HSP90-mediated protein folding (Scholz et al., 2001 [PubMed 11413142]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

337 residues, UniProt reviewed canonical sequence.

>Q7L3B6|CDC37L1
     1  MEQPWPPPGP WSLPRAEGEA EEESDFDVFP SSPRCPQLPG GGAQMYSHGI ELACQKQKEF
    61  VKSSVACKWN LAEAQQKLGS LALHNSESLD QEHAKAQTAV SELRQREEEW RQKEEALVQR
   121  EKMCLWSTDA ISKDVFNKSF INQDKRKDTE DEDKSESFMQ KYEQKIRHFG MLSRWDDSQR
   181  FLSDHPYLVC EETAKYLILW CFHLEAEKKG ALMEQIAHQA VVMQFIMEMA KNCNVDPRGC
   241  FRLFFQKAKA EEEGYFEAFK NELEAFKSRV RLYSQSQSFQ PMTVQNHVPH SGVGSIGLLE
   301  SLPQNPDYLQ YSISTALCSL NSVVHKEDDE PKMMDTV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC37L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 80 nTPM
liver: 51 nTPM
tongue: 49 nTPM
heart muscle: 29 nTPM
blood vessel: 23 nTPM
adipose tissue: 19 nTPM

Single-cell type

thymic myoid cells: 262 nCPM
hepatocytes: 184 nCPM
pituicytes/fscs: 115 nCPM
epicardial cells: 111 nCPM
myonuclei: 105 nCPM
cardiomyocytes: 91 nCPM

Immune cell

basophil: 27 nTPM
naive CD4 T-cell: 26 nTPM
naive CD8 T-cell: 24 nTPM
memory CD8 T-cell: 18 nTPM
T-reg: 17 nTPM
gdT-cell: 17 nTPM

Brain region

hippocampal formation: 25 nTPM
cerebral cortex: 23 nTPM
hypothalamus: 23 nTPM
pons: 23 nTPM
cerebellum: 21 nTPM
midbrain: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.33
gnomAD pLI: 0.97
gnomAD missense Z: -0.14
DepMap mean gene effect: 0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDC37L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC37L1 as an antibody target. Whether an autoantibody or antibody against CDC37L1 could matter depends on whether native CDC37L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC37L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC37L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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