Seroatlas · Human Serome Atlas

FNIP2

Folliculin-interacting protein 2

Also known as: FNIP2_HUMAN, FNIPL, KIAA1450, MAPO1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P278
Gene: FNIP2
Ensembl: ENSG00000052795
Chromosome: 4
Canonical length: 1114 aa
Protein class: Predicted intracellular proteins
Subcellular location: Centriolar satellite,Cytosol
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

1114 residues, UniProt reviewed canonical sequence.

>Q9P278|FNIP2
     1  MAPTLLQKLF NKRGSSGSSA AASAQGRAPK EGPAFSWSCS EFDLNEIRLI VYQDCDRRGR
    61  QVLFDSKAVQ KIEEVTAQKT EDVPIKISAK CCQGSSSVSS SSSSSISSHS SSGGSSHHAK
   121  EQLPKYQYTR PASDVNMLGE MMFGSVAMSY KGSTLKIHYI RSPPQLMISK VFSARMGSFC
   181  GSTNNLQDSF EYINQDPNLG KLNTNQNSLG PCRTGSNLAH STPVDMPSRG QNEDRDSGIA
   241  RSASLSSLLI TPFPSPSSST SSSSSYQRRW LRSQTTSLEN GIIPRRSTDE TFSLAEETCS
   301  SNPAMVRRKK IAISIIFSLC EKEEAQRNFQ DFFFSHFPLF ESHMNRLKSA IEKAMISCRK
   361  IAESSLRVQF YVSRLMEALG EFRGTIWNLY SVPRIAEPVW LTMMSGTLEK NQLCQRFLKE
   421  FTLLIEQINK NQFFAALLTA VLTYHLAWVP TVMPVDHPPI KAFSEKRTSQ SVNMLAKTHP
   481  YNPLWAQLGD LYGAIGSPVR LTRTVVVGKQ KDLVQRILYV LTYFLRCSEL QENQLTWSGN
   541  HGEGDQVLNG SKIITALEKG EVEESEYVVI TVRNEPALVP PILPPTAAER HNPWPTGFPE
   601  CPEGTDSRDL GLKPDKEANR RPEQGSEACS AGCLGPASDA SWKPQNAFCG DEKNKEAPQD
   661  GSSRLPSCEV LGAGMKMDQQ AVCELLKVEM PTRLPDRSVA WPCPDRHLRE KPSLEKVTFQ
   721  IGSFASPESD FESRMKKMEE RVKACGPSLE ASEAADVAQD PQVSRSPFKP GFQENVCCPQ
   781  NRLSEGDEGE SDKGFAEDRG SRNDMAADIA GQLSHAADLG TASHGAGGTG GRRLEATRGL
   841  YVKAAEGPVL EPVAPRCVQR GPGLVAGANI PCGDDNKKAN FRTEGDIPRN ESSDSALGDS
   901  DDEACASAML DLGHGGDRTG GSLEVELPLP RSQSISTQNV RNFGRSLLAG YCPTYMPDLV
   961  LHGTGSDEKL KQCLVADLVH TVHHPVLDEP IAEAVCIIAD TDKWSVQVAT SQRKVTDNMK
  1021  LGQDVLVSSQ VSSLLQSILQ LYKLHLPADF CIMHLEDRLQ EMYLKSKMLS EYLRGHTRVH
  1081  VKELGVVLGI ESNDLPLLTA IASTHSPYVA QILL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FNIP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

liver: 55 nTPM
kidney: 45 nTPM
placenta: 28 nTPM
adipose tissue: 25 nTPM
heart muscle: 24 nTPM
lung: 24 nTPM

Single-cell type

monocytes: 610 nCPM
macrophages: 531 nCPM
cdc: 453 nCPM
renal collecting duct intercalated cells: 427 nCPM
endometrial glandular cells: 425 nCPM
proximal tubule cells: 396 nCPM

Immune cell

non-classical monocyte: 7.2 nTPM
intermediate monocyte: 3.3 nTPM
myeloid DC: 2.1 nTPM
classical monocyte: 0.7 nTPM
naive CD8 T-cell: 0.6 nTPM
NK-cell: 0.6 nTPM

Brain region

thalamus: 63 nTPM
white matter: 50 nTPM
basal ganglia: 40 nTPM
hippocampal formation: 39 nTPM
cerebral cortex: 35 nTPM
medulla oblongata: 35 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.13
gnomAD pLI: 1
gnomAD missense Z: 1.28
DepMap mean gene effect: 0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FNIP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FNIP2 as an antibody target. Whether an autoantibody or antibody against FNIP2 could matter depends on whether native FNIP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FNIP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FNIP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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