CDK13

Protein identityUniProt · HPA

UniProt accession

Q14004

Gene

CDK13

Ensembl

ENSG00000065883

Chromosome

7

Canonical length

1512 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins

Subcellular location

Nuclear speckles,Golgi apparatus,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. The exact function of this protein has not yet been determined, but it may play a role in mRNA processing and may be involved in regulation of hematopoiesis. Alternatively spliced transcript variants have been described.[provided by RefSeq, Dec 2009]

Canonical amino-acid sequenceUniProt

1512 residues, UniProt reviewed canonical sequence.

>Q14004|CDK13
     1  MPSSSDTALG GGGGLSWAEK KLEERRKRRR FLSPQQPPLL LPLLQPQLLQ PPPPPPPLLF
    61  LAAPGTAAAA AAAAAASSSC FSPGPPLEVK RLARGKRRAG GRQKRRRGPR AGQEAEKRRV
   121  FSLPQPQQDG GGGASSGGGV TPLVEYEDVS SQSEQGLLLG GASAATAATA AGGTGGSGGS
   181  PASSSGTQRR GEGSERRPRR DRRSSSGRSK ERHREHRRRD GQRGGSEASK SRSRHSHSGE
   241  ERAEVAKSGS SSSSGGRRKS ASATSSSSSS RKDRDSKAHR SRTKSSKEPP SAYKEPPKAY
   301  REDKTEPKAY RRRRSLSPLG GRDDSPVSHR ASQSLRSRKS PSPAGGGSSP YSRRLPRSPS
   361  PYSRRRSPSY SRHSSYERGG DVSPSPYSSS SWRRSRSPYS PVLRRSGKSR SRSPYSSRHS
   421  RSRSRHRLSR SRSRHSSISP STLTLKSSLA AELNKNKKAR AAEAARAAEA AKAAEATKAA
   481  EAAAKAAKAS NTSTPTKGNT ETSASASQTN HVKDVKKIKI EHAPSPSSGG TLKNDKAKTK
   541  PPLQVTKVEN NLIVDKATKK AVIVGKESKS AATKEESVSL KEKTKPLTPS IGAKEKEQHV
   601  ALVTSTLPPL PLPPMLPEDK EADSLRGNIS VKAVKKEVEK KLRCLLADLP LPPELPGGDD
   661  LSKSPEEKKT ATQLHSKRRP KICGPRYGET KEKDIDWGKR CVDKFDIIGI IGEGTYGQVY
   721  KARDKDTGEM VALKKVRLDN EKEGFPITAI REIKILRQLT HQSIINMKEI VTDKEDALDF
   781  KKDKGAFYLV FEYMDHDLMG LLESGLVHFN ENHIKSFMRQ LMEGLDYCHK KNFLHRDIKC
   841  SNILLNNRGQ IKLADFGLAR LYSSEESRPY TNKVITLWYR PPELLLGEER YTPAIDVWSC
   901  GCILGELFTK KPIFQANQEL AQLELISRIC GSPCPAVWPD VIKLPYFNTM KPKKQYRRKL
   961  REEFVFIPAA ALDLFDYMLA LDPSKRCTAE QALQCEFLRD VEPSKMPPPD LPLWQDCHEL
  1021  WSKKRRRQKQ MGMTDDVSTI KAPRKDLSLG LDDSRTNTPQ GVLPSSQLKS QGSSNVAPVK
  1081  TGPGQHLNHS ELAILLNLLQ SKTSVNMADF VQVLNIKVNS ETQQQLNKIN LPAGILATGE
  1141  KQTDPSTPQQ ESSKPLGGIQ PSSQTIQPKV ETDAAQAAVQ SAFAVLLTQL IKAQQSKQKD
  1201  VLLEERENGS GHEASLQLRP PPEPSTPVSG QDDLIQHQDM RILELTPEPD RPRILPPDQR
  1261  PPEPPEPPPV TEEDLDYRTE NQHVPTTSSS LTDPHAGVKA ALLQLLAQHQ PQDDPKREGG
  1321  IDYQAGDTYV STSDYKDNFG SSSFSSAPYV SNDGLGSSSA PPLERRSFIG NSDIQSLDNY
  1381  STASSHSGGP PQPSAFSESF PSSVAGYGDI YLNAGPMLFS GDKDHRFEYS HGPIAVLANS
  1441  SDPSTGPEST HPLPAKMHNY NYGGNLQENP SGPSLMHGQT WTSPAQGPGY SQGYRGHIST
  1501  STGRGRGRGL PY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDK13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.59

Highest tissue expression

26 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDK13.

Disease | AllUniProt

Conditions CDK13 is implicated in, by any mechanism.

• Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder (CHDFIDD) MIM:617360

Disease | GeneticClinVar

87 pathogenic / likely-pathogenic of 1,179 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Congenital heart defects, dysmorphic facial features, and intellectual developmental disorder
• Inborn genetic diseases
• CDK13-related disorder
• Global developmental delay
• Marfanoid habitus and intellectual disability

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.32

gnomAD pLI

0.91

gnomAD missense Z

2.35

DepMap mean gene effect

-0.09

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• alternative mRNA splicing, via spliceosome
• hemopoiesis
• negative regulation of stem cell differentiation
• positive regulation of transcription by RNA polymerase II
• positive regulation of transcription elongation by RNA polymerase II
• regulation of signal transduction

Molecular functions

• ATP binding
• cyclin binding
• cyclin-dependent protein serine/threonine kinase activity
• protein kinase activity
• protein kinase binding
• protein serine kinase activity
• RNA binding
• RNA polymerase II CTD heptapeptide repeat kinase activity

Cellular components

• cyclin K-CDK13 complex
• cyclin/CDK positive transcription elongation factor complex
• cytosol
• extracellular region
• extracellular space
• ficolin-1-rich granule lumen
• Golgi apparatus
• nuclear cyclin-dependent protein kinase holoenzyme complex
• nuclear speck
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Protein kinase domain
• Serine/threonine-protein kinase, active site
• Protein kinase-like domain superfamily
• Protein kinase, ATP binding site
• Cyclin-dependent kinase
• Protein kinase domain

KeywordsUniProt

• Acetylation
• ATP-binding
• Host-virus interaction
• Intellectual disability
• Isopeptide bond
• Kinase
• mRNA processing
• mRNA splicing
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• RNA editing
• Serine/threonine-protein kinase
• Transferase
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of CDK13 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• C1QBP
• CCNK
• CCNL1
• CCNL2
• CDC37