Seroatlas · Human Serome Atlas

FYN

Tyrosine-protein kinase Fyn

Also known as: FYN_HUMAN, MGC45350, SLK, SYN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P06241
Gene
FYN
Ensembl
ENSG00000010810
Chromosome
6
Canonical length
537 aa
Protein class
Enzymes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

537 residues, UniProt reviewed canonical sequence.

>P06241|FYN
     1  MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG
    61  LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW
   121  EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET
   181  TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC
   241  RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT
   301  LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR
   361  ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY
   421  TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE
   481  RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FYN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.32
Highest tissue expression
109 nTPM

Expression across tissuesHPA

Tissue

  • amygdala: 109 nTPM
  • lymph node: 106 nTPM
  • cerebral cortex: 95 nTPM
  • hippocampal formation: 90 nTPM
  • thymus: 86 nTPM
  • basal ganglia: 84 nTPM

Single-cell type

  • t-cells: 2,001 nCPM
  • nk-cells: 1,966 nCPM
  • innate lymphoid cells: 1,307 nCPM
  • podocytes: 1,093 nCPM
  • oligodendrocytes: 814 nCPM
  • bergmann glia: 771 nCPM

Immune cell

  • MAIT T-cell: 175 nTPM
  • memory CD8 T-cell: 152 nTPM
  • gdT-cell: 137 nTPM
  • memory CD4 T-cell: 84 nTPM
  • T-reg: 79 nTPM
  • naive CD8 T-cell: 72 nTPM

Brain region

  • medulla oblongata: 274 nTPM
  • hypothalamus: 243 nTPM
  • amygdala: 225 nTPM
  • spinal cord: 215 nTPM
  • white matter: 209 nTPM
  • midbrain: 206 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FYN.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 52 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.28
gnomAD pLI
0.99
gnomAD missense Z
4.03
DepMap mean gene effect
-0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FYN in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FYN as an antibody target. Whether an autoantibody or antibody against FYN could matter depends on whether native FYN is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FYN is annotated at the cell surface, where native FYN is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label FYN as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/FYN. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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