IQ motif, EF-hand binding site
IPR000048
Definition
The IQ motif is an extremely basic unit of about 23 amino acids, whose conserved core usually fits the consensus A-x(3)-I-Q-x(2)-F-R-x(4)-K-K. The IQ motif, which can be present in one or more copies, serves as a binding site for different EF-hand proteins, including the essential and regulatory myosin light chains, calmodulin (CaM), CaM-like proteins and Neuromodulin [[cite:PMID:1558751], [cite:PMID:9141499]]. Many IQ motifs are protein kinase C (PKC) phosphorylation sites [[cite:PMID:1824695], [cite:PMID:8424932]]. Resolution of the 3D structure of scallop myosin has shown that the IQ motif forms a basic amphipathic helix PMID:8127365. Some proteins known to contain an IQ motif are listed below: A number of conventional and unconventional myosins. Neuromodulin (GAP-43). This protein is associated with nerve growth. It is a major component of the motile "growth cones" that form the tips of elongating axons. Neurogranin (NG/p17). Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Sperm surface protein Sp17. Ras GTPase-activating-like protein IQGAP1. IQGAP1 contains 4 IQ motifs. This entry covers the entire IQ motif.
55 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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