NRGN

Protein identityUniProt · HPA

UniProt accession

Q92686

Gene

NRGN

Ensembl

ENSG00000154146

Chromosome

11

Canonical length

78 aa

Protein class

Predicted intracellular proteins

OverviewNCBI Gene

Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

78 residues, UniProt reviewed canonical sequence.

>Q92686|NRGN
     1  MDCCTENACS KPDDDILDIP LDDPGANAAA AKIQASFRGH MARKKIKSGE RGRKGPGPGG
    61  PGGAGVARGG AGGGPSGD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRGN can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.63

Highest tissue expression

2,193 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.44

gnomAD pLI

0.48

gnomAD missense Z

1.7

DepMap mean gene effect

0.12

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• associative learning
• nervous system development
• positive regulation of long-term synaptic potentiation
• postsynaptic modulation of chemical synaptic transmission
• signal transduction
• telencephalon development

Molecular functions

• calmodulin binding
• phosphatidic acid binding
• phosphatidylinositol-3,4,5-trisphosphate binding

Cellular components

• axon
• cytosol
• dendritic spine head
• glutamatergic synapse
• mitochondrial membrane
• neuronal cell body
• postsynaptic membrane
• trans-Golgi network transport vesicle membrane

Protein domainsUniProt · Pfam · InterPro

• IQ motif, EF-hand binding site
• IQ calmodulin-binding motif

KeywordsUniProt

• Acetylation
• Calmodulin-binding
• Citrullination
• Methylation
• Phosphoprotein