Seroatlas · Human Serome Atlas

RNF32

RING finger protein 32

Also known as: FKSG33, HSD15, LMBR2, RNF32_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H0A6
Gene: RNF32
Ensembl: ENSG00000105982
Chromosome: 7
Canonical length: 362 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear bodies,Cytosol

OverviewNCBI Gene

The protein encoded by this gene contains two RING ring finger motifs. RING finger motifs are present in a variety of functionally distinct proteins and are known to be involved in protein-DNA or protein-protein interactions. This gene was found to be expressed during spermatogenesis, most likely in spermatocytes and/or in spermatids. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>Q9H0A6|RNF32
     1  MLKNKGHSSK KDNLAVNAVA LQDHILHDLQ LRNLSVADHS KTQVQKKENK SLKRDTKAII
    61  DTGLKKTTQC PKLEDSEKEY VLDPKPPPLT LAQKLGLIGP PPPPLSSDEW EKVKQRSLLQ
   121  GDSVQPCPIC KEEFELRPQV LLSCSHVFHK ACLQAFEKFT NKKTCPLCRK NQYQTRVIHD
   181  GARLFRIKCV TRIQAYWRGC VVRKWYRNLR KTVPPTDAKL RKKFFEKKFT EISHRILCSY
   241  NTNIEELFAE IDQCLAINRS VLQQLEEKCG HEITEEEWEK IQVQALRRET HECSICLAPL
   301  SAAGGQRVGA GRRSREMALL SCSHVFHHAC LLALEEFSVG DRPPFHACPL CRSCYQKKIL
   361  EC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RNF32 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 57 nTPM

Expression across tissuesHPA

Tissue

testis: 57 nTPM
epididymis: 10 nTPM
spinal cord: 3.3 nTPM
fallopian tube: 3 nTPM
stomach: 2.8 nTPM
retina: 2.5 nTPM

Single-cell type

late spermatids: 780 nCPM
late primary spermatocytes: 550 nCPM
early spermatids: 282 nCPM
early primary spermatocytes: 128 nCPM
epicardial cells: 71 nCPM
cardiomyocytes: 42 nCPM

Immune cell

basophil: 13 nTPM
memory B-cell: 2.6 nTPM
plasmacytoid DC: 2.6 nTPM
T-reg: 2 nTPM
naive B-cell: 1.6 nTPM
MAIT T-cell: 1.5 nTPM

Brain region

white matter: 9.3 nTPM
hypothalamus: 8 nTPM
basal ganglia: 7.3 nTPM
medulla oblongata: 6.9 nTPM
pons: 6.9 nTPM
spinal cord: 6.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.54
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: 0.13
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RNF32 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RNF32 as an antibody target. Whether an autoantibody or antibody against RNF32 could matter depends on whether native RNF32 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RNF32 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RNF32 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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