IQCF5
IQ domain-containing protein F5
Also known as: IQCF5_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A8MTL0
- Gene
- IQCF5
- Ensembl
- ENSG00000214681
- Chromosome
- 3
- Canonical length
- 148 aa
- Protein class
- Predicted membrane proteins
OverviewNCBI Gene
Predicted to enable calmodulin binding activity. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
148 residues, UniProt reviewed canonical sequence.
>A8MTL0|IQCF5
1 MGPEEKTIMT ERSAAVFIQA WWRGMLVRRT LLHAALRAWI IQCWWRQVLE KLLAKRRRMV
61 LEFYVQQEWA AVRLQSWVRM WCVRQRYCRL LNAVRIIQVY WRWHSCHSRV FIEGHYELKE
121 NQLNIQLEIS LGLQACKVQQ CIPLPLKELocalizationUniProt · AlphaFold · HPA
Whether an antibody against IQCF5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.49
- Highest tissue expression
- 96 nTPM
Expression across tissuesHPA
Tissue
- testis: 96 nTPM
- adipose tissue: 0 nTPM
- adrenal gland: 0 nTPM
- amygdala: 0 nTPM
- appendix: 0 nTPM
- basal ganglia: 0 nTPM
Single-cell type
- late spermatids: 3,725 nCPM
- early spermatids: 959 nCPM
- late primary spermatocytes: 393 nCPM
- leydig cells: 4.9 nCPM
- sertoli cells: 3.4 nCPM
- peritubular myoid cells: 1.7 nCPM
Immune cell
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
- intermediate monocyte: 0 nTPM
- MAIT T-cell: 0 nTPM
Brain region
- cerebral cortex: 0.6 nTPM
- basal ganglia: 0.4 nTPM
- white matter: 0.4 nTPM
- amygdala: 0.2 nTPM
- cerebellum: 0.2 nTPM
- hippocampal formation: 0.2 nTPM
DiseaseUniProt · ClinVar · IEDB · PubMed
Four sources answering four different questions about IQCF5.
Disease | ImmuneIEDB
Conditions an epitope on IQCF5 was assayed in.
- melanoma T cell
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.19
- gnomAD pLI
- 0.01
- gnomAD missense Z
- 0.7
- DepMap mean gene effect
- -0.07
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads IQCF5 as an antibody target. Whether an autoantibody or antibody against IQCF5 could matter depends on whether native IQCF5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
IQCF5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label IQCF5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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