Seroatlas · Human Serome Atlas

SPEGNB

SPEG neighbor protein

Also known as: SPEGN_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A087WV53
Gene
SPEGNB
Ensembl
ENSG00000286095
Chromosome
2
Canonical length
238 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable protein kinase activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

238 residues, UniProt reviewed canonical sequence.

>A0A087WV53|SPEGNB
     1  MSKAAPAKKP VAVAPAPGCT LDINDPQVQS AAIRIQASYR GHRSRKELRE KGPPRVLEPL
    61  KDVVLIEGSA AKLTCRISAF PDPFIRWSKD GKELRDGPKY RYVFEDPDVV ALVVRDGELA
   121  DLGQYSINVT NPFGQCSDSA RILVEVPTKI QKGPDNTKAR KGTTVTLTAE ILGEPAPDVG
   181  WTKDGEDIEE DDRVFFEIGS TTTTLTIRRA TPQDSGKYEV YVENSLGMDQ SFARVDVA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPEGNB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
4 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 4 nTPM
  • blood vessel: 2.6 nTPM
  • tongue: 2.1 nTPM
  • testis: 1.3 nTPM
  • urinary bladder: 1.3 nTPM
  • colon: 0.8 nTPM

Single-cell type

  • bergmann glia: 9.9 nCPM
  • late spermatids: 8.6 nCPM
  • smooth muscle cells: 8.1 nCPM
  • epididymal principal cells: 5.1 nCPM
  • enterocytes: 3.4 nCPM
  • late primary spermatocytes: 2.6 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 2.5 nTPM
  • basal ganglia: 2.1 nTPM
  • white matter: 2.1 nTPM
  • cerebellum: 2 nTPM
  • pons: 1.9 nTPM
  • hypothalamus: 1.8 nTPM

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPEGNB as an antibody target. Whether an autoantibody or antibody against SPEGNB could matter depends on whether native SPEGNB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPEGNB is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPEGNB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPEGNB. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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