Seroatlas · Human Serome Atlas

IQCD

Dynein regulatory complex protein 10

Also known as: CFAP84, DRC10, DRC10_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96DY2
Gene: IQCD
Ensembl: ENSG00000166578
Chromosome: 12
Canonical length: 449 aa
Protein class: Predicted intracellular proteins
Subcellular location: Mid piece,Principal piece,End piece

OverviewNCBI Gene

Located in ciliary basal body. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

449 residues, UniProt reviewed canonical sequence.

>Q96DY2|IQCD
     1  MALDILAMAP LYQAPAINRI GPKTDPSKRP ADPLKPLVLS RTKLTTIEAK RIMSILDEAI
    61  YKVELVTLLS YVASNREDME GMLGEDVMRA VREHEDLCQV LLENVRCLKE KERQLQEQKE
   121  AEEEGWLRDR LLSIELQKSS LSPLMQQIKD STKNVLRLLL SNPQAARLLQ MQTQGRSAEA
   181  QNFIDSLIEL RGFLFEKLLT SPMEARDKAQ FLQDISRQNS NNQQIIDTLE KELAERMKNR
   241  NAEVEKENFV IQELKNHLHQ VLKFSENSLV RTKQEAEKQQ KADFRASQAR VAKIQQEILQ
   301  LQSQFYNLVM ENREAEQALR KKKYKVETEI ENWIQKYDTE MGEKQEELED LDAVHREEKI
   361  SLEELRRRHK VLVGEFAQIR EEREINSKKR MEAEQEMVRM VRAATLIQAL WKGYLVRSLL
   421  RSKKKRGKGK AKDKEKGKQK GKEKGKGKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCD can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

testis: 42 nTPM
choroid plexus: 21 nTPM
fallopian tube: 21 nTPM
parathyroid gland: 4.8 nTPM
pituitary gland: 3.7 nTPM
retina: 3.5 nTPM

Single-cell type

late primary spermatocytes: 241 nCPM
respiratory ciliated cells: 179 nCPM
fallopian tube ciliated cells: 172 nCPM
early spermatids: 140 nCPM
late spermatids: 135 nCPM
epididymal efferent duct ciliated cells: 103 nCPM

Immune cell

basophil: 1.9 nTPM
plasmacytoid DC: 1.4 nTPM
classical monocyte: 1.1 nTPM
myeloid DC: 0.8 nTPM
memory B-cell: 0.2 nTPM
total PBMC: 0.2 nTPM

Brain region

choroid plexus: 16 nTPM
midbrain: 11 nTPM
medulla oblongata: 8.3 nTPM
white matter: 7 nTPM
spinal cord: 6.7 nTPM
pons: 5.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IQCD.

Disease | ImmuneIEDB

Conditions an epitope on IQCD was assayed in.

hepatocellular carcinoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.85
gnomAD pLI: 0
gnomAD missense Z: 0.06
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

ciliary basal body

Protein domainsUniProt · Pfam · InterPro

IQ motif, EF-hand binding site
IQ calmodulin-binding motif
Dynein regulatory complex protein 10

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCD as an antibody target. Whether an autoantibody or antibody against IQCD could matter depends on whether native IQCD is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCD is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCD as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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