Seroatlas · Human Serome Atlas

IQCF3

IQ domain-containing protein F3

Also known as: IQCF3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P0C7M6
Gene
IQCF3
Ensembl
ENSG00000229972
Chromosome
3
Canonical length
154 aa
Protein class
Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoli

OverviewNCBI Gene

Predicted to enable calmodulin binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>P0C7M6|IQCF3
     1  MGSKCCKGGP DEDAVERQRR QKLLLAQLHH RKRVKAAGQI QAWWRGVLVR RTLLVAALRA
    61  WMIQCWWRTL VQRRIRQRRQ ALLRVYVIQE QATVKLQSCI RMWQCRQCYR QMCNALCLFQ
   121  VPESSLAFQT DGFLQVQYAI PSKQPEFHIE ILSI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCF3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
102 nTPM

Expression across tissuesHPA

Tissue

  • testis: 102 nTPM
  • pancreas: 0.3 nTPM
  • epididymis: 0.2 nTPM
  • cerebral cortex: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • early spermatids: 139 nCPM
  • late spermatids: 120 nCPM
  • late primary spermatocytes: 29 nCPM
  • thymic myoid cells: 1.4 nCPM
  • distal convoluted tubule cells: 0.9 nCPM
  • mast cells: 0.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 1.5 nTPM
  • basal ganglia: 1.1 nTPM
  • cerebral cortex: 1.1 nTPM
  • pons: 1 nTPM
  • hypothalamus: 0.9 nTPM
  • medulla oblongata: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.95
gnomAD pLI
0
gnomAD missense Z
0.4
DepMap mean gene effect
-0.14
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCF3 as an antibody target. Whether an autoantibody or antibody against IQCF3 could matter depends on whether native IQCF3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCF3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCF3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IQCF3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...