IQGAP3

Protein identityUniProt · HPA

UniProt accession

Q86VI3

Gene

IQGAP3

Ensembl

ENSG00000183856

Chromosome

1

Canonical length

1631 aa

Protein class

Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Enables calmodulin binding activity and myosin VI light chain binding activity. Predicted to be involved in mitotic actomyosin contractile ring assembly actin filament organization. Predicted to act upstream of or within several processes, including G1/S transition of mitotic cell cycle; intracellular signaling cassette; and regulation of macromolecule metabolic process. Predicted to be located in cytosol. Predicted to be active in cell cortex. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

1631 residues, UniProt reviewed canonical sequence.

>Q86VI3|IQGAP3
     1  MERRAAGPGW AAYERLTAEE MDEQRRQNVA YQYLCRLEEA KRWMEACLKE ELPSPVELEE
    61  SLRNGVLLAK LGHCFAPSVV PLKKIYDVEQ LRYQATGLHF RHTDNINFWL SAIAHIGLPS
   121  TFFPETTDIY DKKNMPRVVY CIHALSLFLF RLGLAPQIHD LYGKVKFTAE ELSNMASELA
   181  KYGLQLPAFS KIGGILANEL SVDEAAVHAA VLAINEAVER GVVEDTLAAL QNPSALLENL
   241  REPLAAVYQE MLAQAKMEKA ANARNHDDRE SQDIYDHYLT QAEIQGNINH VNVHGALEVV
   301  DDALERQSPE ALLKALQDPA LALRGVRRDF ADWYLEQLNS DREQKAQELG LVELLEKEEV
   361  QAGVAAANTK GDQEQAMLHA VQRINKAIRR RVAADTVKEL MCPEAQLPPV YPVASSMYQL
   421  ELAVLQQQQG ELGQEELFVA VEMLSAVVLI NRALEARDAS GFWSSLVNPA TGLAEVEGEN
   481  AQRYFDALLK LRQERGMGED FLSWNDLQAT VSQVNAQTQE ETDRVLAVSL INEALDKGSP
   541  EKTLSALLLP AAGLDDVSLP VAPRYHLLLV AAKRQKAQVT GDPGAVLWLE EIRQGVVRAN
   601  QDTNTAQRMA LGVAAINQAI KEGKAAQTER VLRNPAVALR GVVPDCANGY QRALESAMAK
   661  KQRPADTAFW VQHDMKDGTA YYFHLQTFQG IWEQPPGCPL NTSHLTREEI QSAVTKVTAA
   721  YDRQQLWKAN VGFVIQLQAR LRGFLVRQKF AEHSHFLRTW LPAVIKIQAH WRGYRQRKIY
   781  LEWLQYFKAN LDAIIKIQAW ARMWAARRQY LRRLHYFQKN VNSIVKIQAF FRARKAQDDY
   841  RILVHAPHPP LSVVRRFAHL LNQSQQDFLA EAELLKLQEE VVRKIRSNQQ LEQDLNIMDI
   901  KIGLLVKNRI TLQEVVSHCK KLTKRNKEQL SDMMVLDKQK GLKSLSKEKR QKLEAYQHLF
   961  YLLQTQPIYL AKLIFQMPQN KTTKFMEAVI FSLYNYASSR REAYLLLQLF KTALQEEIKS
  1021  KVEQPQDVVT GNPTVVRLVV RFYRNGRGQS ALQEILGKVI QDVLEDKVLS VHTDPVHLYK
  1081  NWINQTEAQT GQRSHLPYDV TPEQALSHPE VQRRLDIALR NLLAMTDKFL LAITSSVDQI
  1141  PYGMRYVAKV LKATLAEKFP DATDSEVYKV VGNLLYYRFL NPAVVAPDAF DIVAMAAGGA
  1201  LAAPQRHALG AVAQLLQHAA AGKAFSGQSQ HLRVLNDYLE ETHLKFRKFI HRACQVPEPE
  1261  ERFAVDEYSD MVAVAKPMVY ITVGELVNTH RLLLEHQDCI APDHQDPLHE LLEDLGELPT
  1321  IPDLIGESIA ADGHTDLSKL EVSLTLTNKF EGLEADADDS NTRSLLLSTK QLLADIIQFH
  1381  PGDTLKEILS LSASREQEAA HKQLMSRRQA CTAQTPEPLR RHRSLTAHSL LPLAEKQRRV
  1441  LRNLRRLEAL GLVSARNGYQ GLVDELAKDI RNQHRHRHRR KAELVKLQAT LQGLSTKTTF
  1501  YEEQGDYYSQ YIRACLDHLA PDSKSSGKGK KQPSLHYTAA QLLEKGVLVE IEDLPASHFR
  1561  NVIFDITPGD EAGKFEVNAK FLGVDMERFQ LHYQDLLQLQ YEGVAVMKLF NKAKVNVNLL
  1621  IFLLNKKFLR K

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQGAP3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.31

Highest tissue expression

15 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IQGAP3.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 339 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Motor and sensory neuropathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.85

gnomAD pLI

0

gnomAD missense Z

0.64

DepMap mean gene effect

-0.17

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 10% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• ERK1 and ERK2 cascade
• G1/S transition of mitotic cell cycle
• gene expression
• mammary gland epithelial cell proliferation
• mitotic actomyosin contractile ring assembly actin filament organization
• negative regulation of gene expression
• positive regulation of gene expression
• positive regulation of mammary gland epithelial cell proliferation
• positive regulation of MAPK cascade
• Ras protein signal transduction
• regulation of cell size

Molecular functions

• actin filament binding
• calmodulin binding
• GTPase activator activity
• small GTPase binding
• myosin VI light chain binding

Cellular components

• cell cortex
• cell-cell junction
• cytosol
• lateral plasma membrane

Protein domainsUniProt · Pfam · InterPro

• IQ motif, EF-hand binding site
• IQGAP, helical domain
• Calponin homology domain
• Ras GTPase-activating domain
• Rho GTPase activation protein
• Ras GTPase-activating protein, conserved site
• CH domain superfamily
• Calponin homology (CH) domain
• IQ calmodulin-binding motif
• GTPase-activator protein for Ras-like GTPase
• RasGAP C-terminus

KeywordsUniProt

• Calmodulin-binding
• Phosphoprotein
• Repeat

InteractionsUniProt · HPA

Protein binding partners of IQGAP3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CALM1
• CALM2
• CDC42
• RAC1