Seroatlas · Human Serome Atlas

IQCE

IQ domain-containing protein E

Also known as: IQCE_HUMAN, KIAA1023

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6IPM2
Gene
IQCE
Ensembl
ENSG00000106012
Chromosome
7
Canonical length
695 aa
Protein class
Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location
Nucleoplasm,Nuclear membrane,Plasma membrane,Primary cilium

OverviewNCBI Gene

Involved in limb morphogenesis. Predicted to be located in cytoplasmic side of plasma membrane. Predicted to be part of plasma membrane protein complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

695 residues, UniProt reviewed canonical sequence.

>Q6IPM2|IQCE
     1  MFLGTGEPAL DTGDDSLSAV TFDSDVETKA KRKAFHKPPP TSPKSPYLSK PRKVASWRSL
    61  RTAGSMPLGG RASLTPQKLW LGTAKPGSLT QALNSPLTWE HAWTGVPGGT PDCLTDTFRV
   121  KRPHLRRSAS NGHVPGTPVY REKEDMYDEI IELKKSLHVQ KSDVDLMRTK LRRLEEENSR
   181  KDRQIEQLLD PSRGTDFVRT LAEKRPDASW VINGLKQRIL KLEQQCKEKD GTISKLQTDM
   241  KTTNLEEMRI AMETYYEEVH RLQTLLASSE TTGKKPLGEK KTGAKRQKKM GSALLSLSRS
   301  VQELTEENQS LKEDLDRVLS TSPTISKTQG YVEWSKPRLL RRIVELEKKL SVMESSKSHA
   361  AEPVRSHPPA CLASSSALHR QPRGDRNKDH ERLRGAVRDL KEERTALQEQ LLQRDLEVKQ
   421  LLQAKADLEK ELECAREGEE ERREREEVLR EEIQTLTSKL QELQEMKKEE KEDCPEVPHK
   481  AQELPAPTPS SRHCEQDWPP DSSEEGLPRP RSPCSDGRRD AAARVLQAQW KVYKHKKKKA
   541  VLDEAAVVLQ AAFRGHLTRT KLLASKAHGS EPPSVPGLPD QSSPVPRVPS PIAQATGSPV
   601  QEEAIVIIQS ALRAHLARAR HSATGKRTTT AASTRRRSAS ATHGDASSPP FLAALPDPSP
   661  SGPQALAPLP GDDVNSDDSD DIVIAPSLPT KNFPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCE can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.61
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • testis: 32 nTPM
  • hypothalamus: 15 nTPM
  • cerebral cortex: 15 nTPM
  • amygdala: 15 nTPM
  • spinal cord: 15 nTPM
  • midbrain: 14 nTPM

Single-cell type

  • early spermatids: 562 nCPM
  • late spermatids: 558 nCPM
  • late primary spermatocytes: 185 nCPM
  • respiratory ciliated cells: 138 nCPM
  • endometrial ciliated cells: 98 nCPM
  • undifferentiated spermatogonia: 93 nCPM

Immune cell

  • neutrophil: 3.8 nTPM
  • plasmacytoid DC: 2.4 nTPM
  • eosinophil: 2.1 nTPM
  • intermediate monocyte: 1.2 nTPM
  • classical monocyte: 0.7 nTPM
  • gdT-cell: 0.5 nTPM

Brain region

  • choroid plexus: 62 nTPM
  • midbrain: 55 nTPM
  • amygdala: 54 nTPM
  • cerebral cortex: 54 nTPM
  • hypothalamus: 53 nTPM
  • medulla oblongata: 51 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about IQCE.

Disease | AllUniProt

Conditions IQCE is implicated in, by any mechanism.

Disease | GeneticClinVar

10 pathogenic / likely-pathogenic of 267 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0
gnomAD missense Z
-0.93
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IQCE in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCE as an antibody target. Whether an autoantibody or antibody against IQCE could matter depends on whether native IQCE is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCE is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCE as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IQCE. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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