Seroatlas · Human Serome Atlas

IQCG

Dynein regulatory complex protein 9

Also known as: CFAP122, DKFZp434B227, DRC9, DRC9_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H095
Gene: IQCG
Ensembl: ENSG00000114473
Chromosome: 3
Canonical length: 443 aa
Protein class: Predicted intracellular proteins
Subcellular location: Actin filaments,Cytosol

OverviewNCBI Gene

Enables Hsp70 protein binding activity and calmodulin binding activity. Predicted to be involved in sperm axoneme assembly. Located in actin cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

443 residues, UniProt reviewed canonical sequence.

>Q9H095|IQCG
     1  MEEDSLEDSN LPPKVWHSEM TVSVTGEPPS TVEEEGIPKE TDIEIIPEIP ETLEPLSLPD
    61  VLRISAVLED TTDQLSILNY IMPVQYEGRQ SICVKSREMN LEGTNLDKLP MASTITKIPS
   121  PLITEEGPNL PEIRHRGRFA VEFNKMQDLV FKKPTRQTIM TTETLKKIQI DRQFFSDVIA
   181  DTIKELQDSA TYNSLLQALS KERENKMHFY DIIAREEKGR KQIISLQKQL INVKKEWQFE
   241  VQSQNEYIAN LKDQLQEMKA KSNLENRYMK TNTELQIAQT QKKCNRTEEL LVEEIEKLRM
   301  KTEEEARTHT EIEMFLRKEQ QKLEERLEFW MEKYDKDTEM KQNELNALKA TKASDLAHLQ
   361  DLAKMIREYE QVIIEDRIEK ERSKKKVKQD LLELKSVIKL QAWWRGTMIR REIGGFKMPK
   421  DKVDSKDSKG KGKGKDKRRG KKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 52 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 52 nTPM
fallopian tube: 50 nTPM
testis: 41 nTPM
retina: 17 nTPM
basal ganglia: 13 nTPM
hypothalamus: 12 nTPM

Single-cell type

late spermatids: 666 nCPM
granulosa cells: 454 nCPM
respiratory ciliated cells: 426 nCPM
fallopian tube ciliated cells: 352 nCPM
epididymal efferent duct ciliated cells: 328 nCPM
ependymal cells: 327 nCPM

Immune cell

eosinophil: 4.3 nTPM
memory B-cell: 4.3 nTPM
classical monocyte: 3.8 nTPM
naive CD8 T-cell: 3.7 nTPM
gdT-cell: 3.4 nTPM
myeloid DC: 3.3 nTPM

Brain region

choroid plexus: 52 nTPM
midbrain: 41 nTPM
medulla oblongata: 32 nTPM
spinal cord: 30 nTPM
white matter: 29 nTPM
thalamus: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0
gnomAD missense Z: 0.35
DepMap mean gene effect: 0
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCG as an antibody target. Whether an autoantibody or antibody against IQCG could matter depends on whether native IQCG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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