Seroatlas · Human Serome Atlas

IQCF1

IQ domain-containing protein F1

Also known as: IQCF1_HUMAN, MGC39725

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N6M8
Gene: IQCF1
Ensembl: ENSG00000173389
Chromosome: 3
Canonical length: 205 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable calmodulin binding activity. Predicted to be involved in positive regulation of acrosome reaction and positive regulation of flagellated sperm motility involved in capacitation. Located in acrosomal vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q8N6M8|IQCF1
     1  MEEKQPQKTK EPSKEDEPQQ KEMPTHLSLG AESKAEAKTP VLVETQTVDN ANEKSEKPPE
    61  NQKKLSDKDT VATKIQAWWR GTLVRRALLH AALSACIIQC WWRLILSKIL KKRRQAALEA
   121  FSRKEWAAVT LQSQARMWRI RRRYCQVLNA VRIIQAYWRC RSCASRGFIK GQYRVTANQL
   181  HLQLEILLDS GPCIVTECIP FSIKE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 65 nTPM

Expression across tissuesHPA

Tissue

testis: 65 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 4,488 nCPM
early spermatids: 1,506 nCPM
late primary spermatocytes: 208 nCPM
sertoli cells: 6.7 nCPM
leydig cells: 5.6 nCPM
peritubular myoid cells: 5.2 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
amygdala: 0.1 nTPM
basal ganglia: 0.1 nTPM
cerebellum: 0.1 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.15
gnomAD pLI: 0
gnomAD missense Z: -0.31
DepMap mean gene effect: -0.17
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

calmodulin binding

Cellular components

acrosomal vesicle

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IQCF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCF1 as an antibody target. Whether an autoantibody or antibody against IQCF1 could matter depends on whether native IQCF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCF1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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