Seroatlas · Human Serome Atlas

IQCF6

IQ domain-containing protein F6

Also known as: IQCF6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A8MYZ5
Gene
IQCF6
Ensembl
ENSG00000214686
Chromosome
3
Canonical length
107 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable calmodulin binding activity. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

107 residues, UniProt reviewed canonical sequence.

>A8MYZ5|IQCF6
     1  MVRRTLLQAA LRAWVIQCWW RSMQAKMLEQ RRRLALRLYT CQEWAVVKVQ AQVRMWQARR
    61  RFLQARQAAC IIQSHWRWHA SQTRGLIRGH YEVRASRLEL DIEILMT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • testis: 24 nTPM
  • pancreas: 0.3 nTPM
  • kidney: 0.1 nTPM
  • stomach: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM

Single-cell type

  • early spermatids: 517 nCPM
  • late spermatids: 227 nCPM
  • late primary spermatocytes: 21 nCPM
  • leydig cells: 0.6 nCPM
  • peritubular myoid cells: 0.6 nCPM
  • early primary spermatocytes: 0.5 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 0.3 nTPM
  • hippocampal formation: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • hypothalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0.01
gnomAD missense Z
0.68
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCF6 as an antibody target. Whether an autoantibody or antibody against IQCF6 could matter depends on whether native IQCF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCF6 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IQCF6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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