Seroatlas · Human Serome Atlas

IQCM

IQ domain-containing protein M

Also known as: IQCM_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A0A1B0GVH7
Gene
IQCM
Ensembl
ENSG00000234828
Chromosome
4
Canonical length
501 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for IQCM in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

501 residues, UniProt reviewed canonical sequence.

>A0A1B0GVH7|IQCM
     1  MTTEEAMPEK AKCPTLEITK QDFFQEAKTL IAQHYEKINE NKVQGTSINV FRKKHQKPKS
    61  GKYIPLEIDK KVTRDVVQEH RAALRRICFP KELSKSEHLQ EPPQRISFKE PHIFSRRERC
   121  RPIDLITKGQ VKLDKIMTII EPVSKKMETA KQQHFEESRN RMLELLYPFP VHLYLQPGTS
   181  NLELLKEPDK AFYDWRGFVL TRSFRLACDS RRVSFSQSSS IFRDYYSKTF KTLIKKERQP
   241  IKPEPKSQPR IKGTPNKTDK LDSKVKRIGP HIEIFQVFRE RKKFMITPKL IRMVTVMQAH
   301  VRGWLERKRL QRVMTKALDH GPDMKAVINM YGRLIHRVRY RRGLWRTRQI LNLAELEEWM
   361  DRKKFYEIMF AKREDWPKIE RNELPNFFSD CGHFPTQKQV DDTWDLVHQD GKEKYSELIK
   421  KSKAIEMLFT LYPPEGAHVP DSTLLKSTWL RPIVNGEEGY RYIVNGHPAL KRANIRVVGK
   481  LVARSIRERK MRQHYKSCKV E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IQCM can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.52
Highest tissue expression
4.3 nTPM

Expression across tissuesHPA

Tissue

  • testis: 4.3 nTPM
  • colon: 0.3 nTPM
  • rectum: 0.3 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM

Single-cell type

  • late primary spermatocytes: 231 nCPM
  • early spermatids: 180 nCPM
  • goblet cells: 93 nCPM
  • tuft cells: 92 nCPM
  • colonocytes: 80 nCPM
  • enteric transient amplifying cells: 44 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • white matter: 0.5 nTPM
  • hypothalamus: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM

Protein domainsUniProt · Pfam · InterPro

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IQCM as an antibody target. Whether an autoantibody or antibody against IQCM could matter depends on whether native IQCM is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IQCM is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label IQCM as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/IQCM. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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