Seroatlas · Human Serome Atlas

VPS29

Vacuolar protein sorting-associated protein 29

Also known as: DC15, DC7, PEP11, VPS29_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBQ0
Gene
VPS29
Ensembl
ENSG00000111237
Chromosome
12
Canonical length
182 aa
Protein class
Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>Q9UBQ0|VPS29
     1  MLVLVLGDLH IPHRCNSLPA KFKKLLVPGK IQHILCTGNL CTKESYDYLK TLAGDVHIVR
    61  GDFDENLNYP EQKVVTVGQF KIGLIHGHQV IPWGDMASLA LLQRQFDVDI LISGHTHKFE
   121  AFEHENKFYI NPGSATGAYN ALETNIIPSF VLMDIQASTV VTYVYQLIGD DVKVERIEYK
   181  KP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS29 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.24
Highest tissue expression
121 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 121 nTPM
  • tongue: 94 nTPM
  • blood vessel: 93 nTPM
  • retina: 92 nTPM
  • bone marrow: 91 nTPM
  • epididymis: 85 nTPM

Single-cell type

  • esophageal apical cells: 631 nCPM
  • gastric progenitor cells: 610 nCPM
  • hofbauer cells: 544 nCPM
  • esophageal suprabasal cells: 414 nCPM
  • early primary spermatocytes: 380 nCPM
  • megakaryocytes: 334 nCPM

Immune cell

  • non-classical monocyte: 407 nTPM
  • total PBMC: 385 nTPM
  • intermediate monocyte: 357 nTPM
  • myeloid DC: 319 nTPM
  • classical monocyte: 263 nTPM
  • eosinophil: 260 nTPM

Brain region

  • cerebral cortex: 39 nTPM
  • white matter: 37 nTPM
  • hypothalamus: 31 nTPM
  • spinal cord: 30 nTPM
  • medulla oblongata: 29 nTPM
  • pons: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.53
gnomAD pLI
0.75
gnomAD missense Z
1.7
DepMap mean gene effect
-0.47
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Metallo-dependent phosphatase-like
  • Phosphodiesterase MJ0936/Vps29
  • Calcineurin-like phosphoesterase domain, lpxH-type
  • Vacuolar protein sorting-associated protein 29
  • Calcineurin-like phosphoesterase superfamily domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS29 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS29 as an antibody target. Whether an autoantibody or antibody against VPS29 could matter depends on whether native VPS29 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS29 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS29 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/VPS29. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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