Seroatlas · Human Serome Atlas

DENND10

DENN domain-containing protein 10

Also known as: DEN10_HUMAN, FAM45A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TCE6
Gene: DENND10
Ensembl: ENSG00000119979
Chromosome: 10
Canonical length: 357 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endosome transport via multivesicular body sorting pathway; protein transport; and regulation of early endosome to late endosome transport. Located in late endosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q8TCE6|DENND10
     1  MAAAEVADTQ LMLGVGLIEK DTNGEVLWVW CYPSTTATLR NLLLRKCCLT DENKLLHPFV
    61  FGQYRRTWFY ITTIEVPDSS ILKKVTHFSI VLTAKDFNPE KYAAFTRILC RMYLKHGSPV
   121  KMMESYIAVL TKGICQSEEN GSFLSKDFDA RKAYLAGSIK DIVSQFGMET VILHTALMLK
   181  KRIVVYHPKI EAVQEFTRTL PALVWHRQDW TILHSYVHLN ADELEALQMC TGYVAGFVDL
   241  EVSNRPDLYD VFVNLAESEI TIAPLAKEAM AMGKLHKEMG QLIVQSAEDP EKSESHVIQD
   301  IALKTREIFT NLAPFSEVSA DGEKRVLNLE ALKQKRFPPA TENFLYHLAA AEQMLKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DENND10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.26
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 31 nTPM
liver: 29 nTPM
kidney: 24 nTPM
esophagus: 20 nTPM
ovary: 20 nTPM
spinal cord: 20 nTPM

Single-cell type

esophageal apical cells: 181 nCPM
neutrophils: 148 nCPM
monocytes: 90 nCPM
monocyte progenitors: 85 nCPM
hofbauer cells: 80 nCPM
neutrophil progenitors: 80 nCPM

Immune cell

eosinophil: 56 nTPM
basophil: 45 nTPM
neutrophil: 40 nTPM
non-classical monocyte: 37 nTPM
intermediate monocyte: 32 nTPM
classical monocyte: 27 nTPM

Brain region

white matter: 26 nTPM
cerebral cortex: 24 nTPM
basal ganglia: 23 nTPM
spinal cord: 23 nTPM
medulla oblongata: 23 nTPM
pons: 23 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.11
gnomAD pLI: 0
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

late endosome

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DENND10 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DENND10 as an antibody target. Whether an autoantibody or antibody against DENND10 could matter depends on whether native DENND10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DENND10 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DENND10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...