Seroatlas · Human Serome Atlas

COMMD9

COMM domain-containing protein 9

Also known as: COMD9_HUMAN, FLJ31106, HSPC166

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9P000
Gene: COMMD9
Ensembl: ENSG00000110442
Chromosome: 11
Canonical length: 198 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to be involved in sodium ion transport. Predicted to act upstream of or within cholesterol homeostasis. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

198 residues, UniProt reviewed canonical sequence.

>Q9P000|COMMD9
     1  MAALTAEHFA ALQSLLKASS KDVVRQLCQE SFSSSALGLK KLLDVTCSSL SVTQEEAEEL
    61  LQALHRLTRL VAFRDLSSAE AILALFPENF HQNLKNLLTK IILEHVSTWR TEAQANQISL
   121  PRLVDLDWRV DIKTSSDSIS RMAVPTCLLQ MKIQEDPSLC GDKPSISAVT VELSKETLDT
   181  MLDGLGRIRD QLSAVASK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COMMD9 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 60 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 60 nTPM
tongue: 58 nTPM
bone marrow: 48 nTPM
kidney: 40 nTPM
spinal cord: 36 nTPM
cerebral cortex: 35 nTPM

Single-cell type

oocytes: 129 nCPM
hofbauer cells: 111 nCPM
esophageal suprabasal cells: 92 nCPM
esophageal basal cells: 74 nCPM
esophageal apical cells: 71 nCPM
monocytes: 66 nCPM

Immune cell

myeloid DC: 384 nTPM
classical monocyte: 378 nTPM
intermediate monocyte: 360 nTPM
total PBMC: 315 nTPM
non-classical monocyte: 302 nTPM
eosinophil: 174 nTPM

Brain region

white matter: 43 nTPM
spinal cord: 40 nTPM
thalamus: 38 nTPM
cerebellum: 36 nTPM
midbrain: 35 nTPM
medulla oblongata: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.39
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

COMM domain
COMM domain
COMM domain-containing protein 9
COMMD9, N-terminal domain
COMMD9, helical N-terminal domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COMMD9 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COMMD9 as an antibody target. Whether an autoantibody or antibody against COMMD9 could matter depends on whether native COMMD9 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COMMD9 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COMMD9 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...