Seroatlas · Human Serome Atlas

VPS26A

Vacuolar protein sorting-associated protein 26A

Also known as: Hbeta58, PEP8A, VP26A_HUMAN, VPS26

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75436
Gene: VPS26A
Ensembl: ENSG00000122958
Chromosome: 10
Canonical length: 327 aa
Protein class: Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location: Endosomes,Lysosomes

OverviewNCBI Gene

This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>O75436|VPS26A
     1  MSFLGGFFGP ICEIDIVLND GETRKMAEMK TEDGKVEKHY LFYDGESVSG KVNLAFKQPG
    61  KRLEHQGIRI EFVGQIELFN DKSNTHEFVN LVKELALPGE LTQSRSYDFE FMQVEKPYES
   121  YIGANVRLRY FLKVTIVRRL TDLVKEYDLI VHQLATYPDV NNSIKMEVGI EDCLHIEFEY
   181  NKSKYHLKDV IVGKIYFLLV RIKIQHMELQ LIKKEITGIG PSTTTETETI AKYEIMDGAP
   241  VKGESIPIRL FLAGYDPTPT MRDVNKKFSV RYFLNLVLVD EEDRRYFKQQ EIILWRKAPE
   301  KLRKQRTNFH QRFESPESQA SAEQPEM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against VPS26A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 40 nTPM

Expression across tissuesHPA

Tissue

testis: 40 nTPM
esophagus: 39 nTPM
cerebellum: 38 nTPM
placenta: 38 nTPM
parathyroid gland: 36 nTPM
adipose tissue: 35 nTPM

Single-cell type

syncytiotrophoblasts: 331 nCPM
neutrophils: 298 nCPM
esophageal apical cells: 270 nCPM
cytotrophoblasts: 151 nCPM
neutrophil progenitors: 148 nCPM
sertoli cells: 146 nCPM

Immune cell

NK-cell: 55 nTPM
basophil: 55 nTPM
intermediate monocyte: 47 nTPM
myeloid DC: 45 nTPM
total PBMC: 44 nTPM
memory CD8 T-cell: 42 nTPM

Brain region

white matter: 33 nTPM
cerebellum: 30 nTPM
spinal cord: 29 nTPM
medulla oblongata: 28 nTPM
hypothalamus: 27 nTPM
midbrain: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.48
gnomAD pLI: 0.61
gnomAD missense Z: 1.56
DepMap mean gene effect: -0.27
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of VPS26A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads VPS26A as an antibody target. Whether an autoantibody or antibody against VPS26A could matter depends on whether native VPS26A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

VPS26A is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label VPS26A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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