Seroatlas · Human Serome Atlas

SNX27

Sorting nexin-27

Also known as: KIAA0488, MGC20471, MY014, SNX27_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96L92
Gene
SNX27
Ensembl
ENSG00000143376
Chromosome
1
Canonical length
541 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

541 residues, UniProt reviewed canonical sequence.

>Q96L92|SNX27
     1  MADEDGEGIH PSAPHRNGGG GGGGGSGLHC AGNGGGGGGG PRVVRIVKSE SGYGFNVRGQ
    61  VSEGGQLRSI NGELYAPLQH VSAVLPGGAA DRAGVRKGDR ILEVNHVNVE GATHKQVVDL
   121  IRAGEKELIL TVLSVPPHEA DNLDPSDDSL GQSFYDYTEK QAVPISVPRY KHVEQNGEKF
   181  VVYNVYMAGR QLCSKRYREF AILHQNLKRE FANFTFPRLP GKWPFSLSEQ QLDARRRGLE
   241  EYLEKVCSIR VIGESDIMQE FLSESDENYN GVSDVELRVA LPDGTTVTVR VKKNSTTDQV
   301  YQAIAAKVGM DSTTVNYFAL FEVISHSFVR KLAPNEFPHK LYIQNYTSAV PGTCLTIRKW
   361  LFTTEEEILL NDNDLAVTYF FHQAVDDVKK GYIKAEEKSY QLQKLYEQRK MVMYLNMLRT
   421  CEGYNEIIFP HCACDSRRKG HVITAISITH FKLHACTEEG QLENQVIAFE WDEMQRWDTD
   481  EEGMAFCFEY ARGEKKPRWV KIFTPYFNYM HECFERVFCE LKWRKENIFQ MARSQQRDVA
   541  T

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNX27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
22 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 22 nTPM
  • basal ganglia: 21 nTPM
  • tongue: 20 nTPM
  • skeletal muscle: 20 nTPM
  • spinal cord: 19 nTPM
  • midbrain: 18 nTPM

Single-cell type

  • neutrophils: 527 nCPM
  • syncytiotrophoblasts: 206 nCPM
  • neutrophil progenitors: 178 nCPM
  • kupffer cells: 155 nCPM
  • monocytes: 143 nCPM
  • monocyte progenitors: 130 nCPM

Immune cell

  • neutrophil: 41 nTPM
  • classical monocyte: 36 nTPM
  • non-classical monocyte: 35 nTPM
  • intermediate monocyte: 31 nTPM
  • basophil: 22 nTPM
  • total PBMC: 17 nTPM

Brain region

  • basal ganglia: 66 nTPM
  • hypothalamus: 64 nTPM
  • midbrain: 62 nTPM
  • medulla oblongata: 61 nTPM
  • pons: 60 nTPM
  • white matter: 60 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SNX27.

Disease | GeneticClinVar

22 pathogenic / likely-pathogenic of 484 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
2.17
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 13% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNX27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNX27 as an antibody target. Whether an autoantibody or antibody against SNX27 could matter depends on whether native SNX27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNX27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNX27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SNX27. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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